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Rabbit Polyclonal MT-ND3 Antibody

  • 中文名： MT-ND3抗体
  • 别    名： MTND3; ND3
货号: IPDX11960
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesMTND3; ND3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MT-ND3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于MT-ND3抗体的虚构参考文献示例(仅供格式参考，实际文献请通过学术数据库查询)：

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1. **文献名称**: *MT-ND3 mutations and antibody-based detection in Leigh syndrome*

**作者**: DiMauro S, et al.

**摘要**: 本研究利用MT-ND3特异性抗体分析了12例Leigh综合征患者的线粒体复合物I组装缺陷，发现3例携带m.10158T>C突变，抗体检测显示ND3蛋白表达显著降低，提示其与神经退行性病变的相关性。

2. **文献名称**: *Antibody profiling of mitochondrial complex I subunits in Parkinson's disease*

**作者**: Wallace DC, et al.

**摘要**: 通过MT-ND3抗体对帕金森病患者脑组织进行免疫组化分析，发现黑质区域线粒体复合物I的ND3亚基表达异常，可能与氧化应激和神经元死亡相关。

3. **文献名称**: *Role of MT-ND3 in cardiac ischemia-reperfusion injury: An antibody-mediated study*

**作者**: Chen H, et al.

**摘要**: 利用MT-ND3抗体研究心肌缺血再灌注损伤模型，发现ND3蛋白水平下降导致复合物I功能障碍，加剧活性氧(ROS)累积，提示其作为潜在治疗靶点。

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**注意**：以上文献为示例，实际研究需通过PubMed、Web of Science等平台检索关键词(如“MT-ND3 antibody”、“ND3 mitochondrial disease”)获取真实数据。

背景信息

The MT-ND3 antibody is a tool used to detect the MT-ND3 protein, a subunit of NADH dehydrogenase (Complex I) in the mitochondrial electron transport chain. Encoded by the mitochondrial genome (MT-ND3 gene), this protein is essential for oxidative phosphorylation, the process that generates cellular ATP. MT-ND3 localizes to the inner mitochondrial membrane and contributes to Complex I assembly and function, facilitating electron transfer from NADH to ubiquinone. Mutations in the MT-ND3 gene are linked to mitochondrial disorders, including Leigh syndrome, mitochondrial encephalopathy, and Leber’s hereditary optic neuropathy (LHON), often characterized by impaired energy metabolism and neurodegeneration. Researchers use MT-ND3 antibodies in techniques like Western blotting, immunofluorescence, or immunohistochemistry to study mitochondrial dysfunction, disease mechanisms, or protein expression patterns in tissues or cell models. These antibodies help investigate how MT-ND3 variations or deficiencies affect cellular respiration, reactive oxygen species (ROS) production, or apoptosis. Commercial MT-ND3 antibodies are typically validated for specificity using knockout controls or peptide blocking assays. Their applications span basic research in metabolism, neurodegenerative diseases, cancer (where mitochondrial defects are common), and therapeutic development targeting mitochondrial pathways.

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