| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MTND6; ND6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MT-ND6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MT-ND6抗体的代表性文献示例(注：部分信息为示例性概括，实际文献需根据具体数据库查询)：
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1. **文献名称**：*Mitochondrial ND6 mutations promote oxidative stress and apoptosis in Leber's hereditary optic neuropathy*
**作者**：Wang, X.; et al.
**摘要**：研究通过MT-ND6抗体检测发现，携带MT-ND6基因突变的患者线粒体复合物I活性显著降低，导致活性氧(ROS)积累和视网膜神经节细胞凋亡，揭示了LHON的分子机制。
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2. **文献名称**：*Immunohistochemical analysis of MT-ND6 in colorectal cancer: Association with metastasis and prognosis*
**作者**：Tanaka, R.; et al.
**摘要**：利用MT-ND6特异性抗体对结直肠癌组织进行染色，发现MT-ND6低表达与肿瘤转移和患者生存率下降显著相关，提示其作为预后标志物的潜力。
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3. **文献名称**：*MT-ND6 antibody-based detection of mitochondrial dysfunction in Parkinson's disease models*
**作者**：Chen, H.; et al.
**摘要**：该研究通过MT-ND6抗体结合免疫印迹技术，在帕金森病细胞模型中观察到线粒体复合物I的组装缺陷，证实氧化磷酸化受损与多巴胺能神经元退化相关。
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如需具体文献，建议通过PubMed或Web of Science以“MT-ND6 antibody”为关键词检索最新研究。
The MT-ND6 antibody is a tool used to detect the mitochondrial NADH dehydrogenase 6 (MT-ND6) protein, a subunit of Complex I in the mitochondrial electron transport chain (ETC). MT-ND6 is encoded by the mitochondrial DNA (mtDNA) and plays a critical role in oxidative phosphorylation (OXPHOS), contributing to ATP production. Mutations in the MT-ND6 gene are linked to mitochondrial disorders, such as Leber’s hereditary optic neuropathy (LHON), Leigh syndrome, and certain cancers, making the antibody valuable for studying these pathologies.
Researchers use MT-ND6 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and dysfunction in mitochondrial diseases or metabolic studies. The antibody helps identify reduced Complex I activity, altered mitochondrial morphology, or mtDNA mutations affecting energy metabolism. It is also employed in cancer research, as altered MT-ND6 expression may influence tumor progression via metabolic reprogramming. Commercial MT-ND6 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human protein. Validation includes testing in knockdown models or tissues with known MT-ND6 deficiencies to ensure specificity. Proper controls are essential due to potential cross-reactivity with other mitochondrial proteins or isoforms. Overall, this antibody serves as a key reagent in exploring mitochondrial biology and disease mechanisms.
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