| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MASK; MST4 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human STK26 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STK26抗体的3篇参考文献示例(内容为虚构，仅用于演示格式)：
1. **文献名称**: "STK26 regulates cell polarity and migration in colorectal cancer"
**作者**: Madison, J.R. et al.
**摘要**: 该研究利用STK26特异性抗体，通过免疫荧光和Western blot分析，发现STK26通过调控细胞极性相关蛋白(如PAR3)的磷酸化，促进结肠癌细胞的迁移和侵袭。
2. **文献名称**: "MST4/STK26 modulates hepatic lipid metabolism under metabolic stress"
**作者**: Zhang, Y. et al.
**摘要**: 作者使用STK26抗体检测其在肝细胞中的表达，发现STK26在高脂饮食模型中激活AMPK信号通路，影响脂质代谢，表明其可能成为代谢性疾病的治疗靶点。
3. **文献名称**: "STK26 interacts with TLR4 to regulate innate immune responses"
**作者**: Lee, S. et al.
**摘要**: 研究通过免疫共沉淀(Co-IP)结合STK26抗体，揭示STK26与TLR4受体结合并增强NF-κB信号通路，促进巨噬细胞中炎症因子的产生。
4. **文献名称**: "Developmental role of STK26 in neuronal morphogenesis"
**作者**: Sasaki, T. et al.
**摘要**: 利用STK26抗体进行组织特异性敲除实验，发现STK26在小鼠胚胎脑发育中调控神经元突起的形成和轴突导向。
(注：以上文献及作者为虚构示例，实际引用需检索PubMed或Google Scholar等数据库获取真实文献。)
The STK26 antibody is designed to target serine/threonine kinase 26 (STK26), also known as mammalian STE20-like kinase 4 (MST4), a member of the germinal center kinase III subfamily. STK26 is a ubiquitously expressed protein kinase involved in regulating cell polarity, proliferation, apoptosis, and stress responses. It interacts with signaling pathways such as the ERK and JNK cascades, often through phosphorylation of downstream substrates. STK26 localizes to the Golgi apparatus and plasma membrane, where it participates in maintaining cellular structure and function, particularly in response to oxidative or osmotic stress.
Antibodies against STK26 are widely used in research to study its expression, localization, and mechanistic roles in physiological and pathological contexts. These antibodies (monoclonal or polyclonal) are typically validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). STK26 has garnered attention in cancer research due to its dual role in promoting or suppressing tumor growth, depending on the cellular context. For instance, it may inhibit colorectal cancer progression by modulating apoptosis but enhance migration in hepatocellular carcinoma. Dysregulation of STK26 is also linked to inflammatory diseases and metabolic disorders. Researchers utilize STK26 antibodies to explore its potential as a therapeutic target or biomarker, though its complex regulatory networks warrant further investigation.
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