| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MIFR; MMP22; MIFR-1; MMP23A |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP23B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP23B抗体的3篇参考文献示例(注：以下文献为示例性内容，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*"Characterization of a novel monoclonal antibody against human MMP23B and its application in ovarian cancer diagnostics"*
**作者**：Zhang Y, et al.
**摘要**：本研究开发了一种针对MMP23B的新型单克隆抗体，验证了其在免疫组化和Western blot中的特异性，并发现MMP23B在卵巢癌组织中高表达，提示其作为生物标志物的潜力。
2. **文献名称**：*"MMP23B in extracellular matrix remodeling: Insights from antibody-mediated functional inhibition studies"*
**作者**：Lee S, Kim JH.
**摘要**：通过使用特异性抗体阻断MMP23B的活性，研究发现其在胶原降解和肿瘤微环境调控中发挥关键作用，为靶向治疗提供了实验依据。
3. **文献名称**：*"Expression profiling and antibody validation of MMP23B in inflammatory diseases"*
**作者**：Garcia A, et al.
**摘要**：文章系统评估了MMP23B在类风湿性关节炎等炎症疾病中的表达模式，并验证了商用抗体的可靠性，揭示了其与炎症介质的相关性。
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如需获取真实文献，建议在 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)或 **Google Scholar** 中检索关键词 "MMP23B antibody"。
The MMP23B antibody is designed to detect Matrix Metalloproteinase 23B (MMP23B), a member of the MMP family, which plays roles in extracellular matrix (ECM) remodeling and tissue homeostasis. Unlike many MMPs, MMP23B is synthesized as a type II transmembrane protein with a unique structure, lacking a conserved hinge region and hemopexin domain. It is encoded by the *MMP23* gene, located on chromosome 1p36.3. and is expressed predominantly in reproductive tissues, the liver, and certain cancers. MMP23B is implicated in processes like inflammation, angiogenesis, and cancer progression, though its precise mechanisms remain under investigation.
MMP23B antibodies are primarily used in research to study the protein's localization, expression levels, and functional roles via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in exploring MMP23B's involvement in pathologies, including tumor metastasis, osteoarthritis, and cardiovascular diseases. Commercial antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Recent studies highlight MMP23B's potential as a biomarker or therapeutic target, particularly in cancers where dysregulated ECM remodeling drives invasiveness. However, its dual roles in promoting or inhibiting disease progression, depending on context, underscore the need for further research to clarify its biological significance.
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