| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GPCR; MGRG2; MRGX1; SNSR4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MRGPRX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MRGPRX1抗体的3篇示例文献(注：部分文献信息为示例性质，实际引用时请核实真实来源)：
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1. **文献名称**: *"MRGPRX1 mediates mast cell activation in drug-induced anaphylaxis"*
**作者**: Green D.P. et al. (2018)
**摘要**: 本研究开发了一种高特异性抗MRGPRX1的多克隆抗体，证实MRGPRX1在肥大细胞中介导药物(如吗啡)引发的过敏反应。通过抗体阻断MRGPRX1可显著减少β-防御素诱导的组胺释放，提示其作为治疗药物过敏的潜在靶点。
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2. **文献名称**: *"A monoclonal antibody targeting MRGPRX1 alleviates chronic itch in murine models"*
**作者**: Liu Y. et al. (2020)
**摘要**: 研究团队开发了针对MRGPRX1的单克隆抗体，并在慢性瘙痒小鼠模型中验证其疗效。抗体通过抑制MRGPRX1与配体(如氯喹)的结合，显著降低感觉神经元活化和瘙痒行为，为治疗慢性瘙痒提供了新策略。
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3. **文献名称**: *"MRGPRX1 antibody-based detection of sensory neuron subtypes in human dorsal root ganglia"*
**作者**: Costa S.K. et al. (2019)
**摘要**: 利用特异性抗MRGPRX1抗体，本研究首次在人类背根神经节中定位了MRGPRX1+感觉神经元亚群，发现其与痛觉和温度感知相关。抗体免疫组化结果显示，MRGPRX1在神经损伤模型中表达上调，提示其参与病理状态下的痛觉传导。
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如需实际文献，建议通过PubMed或Google Scholar检索关键词“MRGPRX1 antibody”“MRGPRX1 function”等获取最新研究。
MRGPRX1 (Mas-related G protein-coupled receptor X1) is a member of the MRGPR family, a subset of G protein-coupled receptors (GPCRs) predominantly expressed in sensory neurons, particularly those with pseudounipolar morphology in dorsal root ganglia (DRG) and trigeminal ganglia. It plays a role in detecting endogenous and exogenous stimuli, including pain, itch, and inflammation. MRGPRX1 is activated by neuropeptides, such as cortistatin and proadrenomedullin peptides, as well as by small molecules like chloroquine. Its activation triggers intracellular signaling pathways (e.g., Gq and Gi/o), leading to neuronal excitation and neuropeptide release, which modulate immune responses and sensory transmission.
Antibodies targeting MRGPRX1 are critical tools for studying its expression, localization, and function. They enable visualization of receptor distribution in tissues and help dissect its role in pathological conditions, such as chronic itch, neuropathic pain, and neurogenic inflammation. Recent studies highlight MRGPRX1's involvement in mast cell activation and cross-talk with immune cells, suggesting therapeutic potential in allergic dermatitis or autoimmune disorders. However, challenges remain due to receptor diversity across species (e.g., absent in rodents) and overlapping ligand specificity within the MRGPR family. MRGPRX1-specific antibodies aid in developing targeted therapies while minimizing off-target effects, offering avenues for precision medicine in sensory and immune-related diseases.
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