| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NIRF; URF2; RNF107 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human UHRF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UHRF2抗体的示例性参考文献，供参考：
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1. **"UHRF2 Antibody Development and Its Role in DNA Methylation"**
*作者：Zhang Y, et al.*
**摘要**：本研究开发了一种高特异性UHRF2多克隆抗体，并通过Western blot和免疫荧光验证其可靠性。实验表明，UHRF2通过调控DNA甲基转移酶活性参与表观遗传修饰，尤其在结肠癌细胞中高表达。
2. **"Monoclonal Antibody Against UHRF2 Reveals Its Interaction with Histone Modifiers"**
*作者：Lee S, et al.*
**摘要**：团队制备了抗UHRF2单克隆抗体，用于免疫共沉淀和质谱分析，发现UHRF2与组蛋白去乙酰化酶(HDACs)相互作用，提示其在染色质重塑和基因沉默中的潜在作用。
3. **"UHRF2 Expression in Hepatocellular Carcinoma: A Study Using Custom Antibodies"**
*作者：Wang X, et al.*
**摘要**：通过定制UHRF2抗体进行免疫组化分析，发现其在肝癌组织中显著高表达，且与患者预后不良相关。研究支持UHRF2作为癌症生物标志物的可能性。
4. **"Functional Characterization of UHRF2 in Cell Cycle via Antibody-Mediated Knockdown"**
*作者：Tanaka R, et al.*
**摘要**：利用UHRF2抗体进行功能阻断实验，结合siRNA技术，证明UHRF2通过调控Cyclin D1影响细胞周期G1/S转换，提示其作为抗癌治疗靶点的潜力。
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*注：以上文献为示例，实际引用需根据具体研究检索真实文献。建议通过PubMed或Google Scholar以“UHRF2 antibody”为关键词查找最新论文。*
UHRF2 (Ubiquitin-like with PHD and RING Finger domains 2) is a multifunctional protein involved in epigenetic regulation, particularly in DNA methylation and histone modification. It belongs to the UHRF family, alongside UHRF1. sharing structural similarities such as tandem Tudor, PHD, and RING finger domains. These domains enable UHRF2 to interact with histone marks (e.g., H3K9me3) and DNA, facilitating chromatin remodeling and gene silencing. Unlike UHRF1. which is cell cycle-regulated and critical in maintaining DNA methylation during replication, UHRF2 exhibits broader tissue expression, including high levels in the brain and testes, suggesting roles in neurodevelopment and spermatogenesis.
Antibodies targeting UHRF2 are essential tools for studying its localization, expression, and interactions. They are commonly used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore UHRF2's involvement in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Research has linked UHRF2 dysregulation to cancers, neurodegenerative diseases, and developmental disorders, highlighting its therapeutic potential. However, challenges remain in distinguishing UHRF2-specific functions from UHRF1 due to overlapping roles. Validated UHRF2 antibodies are critical for dissecting its unique contributions to epigenetic networks and disease mechanisms.
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