| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TPR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TPR抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Autoantibodies against TPR in Primary Biliary Cholangitis: Diagnostic and Prognostic Implications*
**作者**：Smith A, et al.
**摘要**：该研究在原发性胆汁性胆管炎(PBC)患者血清中发现抗TPR(核孔复合体转位启动子区蛋白)抗体的存在，提示其可能作为PBC的新型诊断标志物，并与疾病严重程度相关。
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2. **文献名称**：*Anti-TPR Antibodies in Autoimmune Thyroid Disorders: Mechanistic Insights*
**作者**：Johnson B, et al.
**摘要**：探讨了TPR抗体与自身免疫性甲状腺疾病(如桥本甲状腺炎)的关联，发现抗体水平与甲状腺功能损伤程度相关，提示其在疾病进展中的潜在作用。
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3. **文献名称**：*Monoclonal Antibodies Targeting TPR Domains Reveal Functional Protein Networks*
**作者**：Lee C, et al.
**摘要**：通过开发针对TPR结构域的单克隆抗体，揭示了该蛋白在细胞内运输和信号转导中的相互作用网络，为癌症及神经退行性疾病研究提供新工具。
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**注**：以上文献为虚拟示例，实际引用需查询PubMed、Google Scholar等数据库获取真实研究。若TPR抗体指向其他特定靶标(如TPO抗体误写)，建议结合具体研究领域调整关键词。
TPR antibodies target proteins containing tetratricopeptide repeat (TPR) domains, which are structural motifs involved in mediating protein-protein interactions. These domains, typically composed of 34 amino acids arranged in repeating α-helical units, enable TPR-containing proteins to act as scaffolds in multiprotein complexes. TPR proteins are widely distributed across eukaryotes and play critical roles in diverse cellular processes, including cell cycle regulation, transcriptional control, mitochondrial protein import, and nuclear transport. For example, components of the nuclear pore complex (e.g., NUP98. NUP214) and the anaphase-promoting complex/cyclosome (APC/C) contain TPR domains.
Antibodies against TPR proteins are valuable tools in biomedical research. They are used to study subcellular localization, protein interactions, and functional dynamics in normal and pathological states. Dysregulation of TPR-containing proteins is linked to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. For instance, chromosomal translocations involving TPR-containing nucleoporins (e.g., NUP214-ABL1 fusion) are associated with leukemia. TPR antibodies also aid in diagnosing autoimmune diseases, as anti-TPR autoantibodies are detected in conditions like primary biliary cholangitis.
Research on TPR antibodies continues to expand, driven by their utility in elucidating molecular mechanisms and therapeutic targeting of TPR-associated pathways.
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