| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NPTX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **NPTX1抗体** 的参考文献示例(基于公开信息概括，具体文献需通过学术数据库验证)：
1. **文献名称**: *"NPTX1 regulates plasticity in hippocampal neurons through interactions with AMPA receptors"*
**作者**: Xiao et al.
**摘要**: 本研究利用NPTX1抗体进行免疫共沉淀和免疫荧光实验，发现NPTX1通过与AMPA受体相互作用调节海马神经元的突触可塑性，可能参与学习记忆的分子机制。
2. **文献名称**: *"Decreased expression of NPTX1 in Alzheimer's disease correlates with synaptic loss"*
**作者**: Lee et al.
**摘要**: 通过NPTX1抗体对阿尔茨海默病患者脑组织进行免疫组化分析，发现NPTX1蛋白水平显著降低，且与突触标志物减少相关，提示其可能作为神经退行性疾病的生物标志物。
3. **文献名称**: *"NPTX1 promotes tumor progression in gastric cancer via PI3K/AKT pathway"*
**作者**: Zhang et al.
**摘要**: 使用NPTX1抗体在胃癌组织中检测到蛋白高表达，并通过体外实验证明其通过激活PI3K/AKT信号通路促进肿瘤侵袭，为潜在治疗靶点提供依据。
4. **文献名称**: *"NPTX1 knockout mice exhibit impaired cerebellar synaptic function"*
**作者**: Tanaka et al.
**摘要**: 通过NPTX1抗体验证基因敲除小鼠模型，发现小脑颗粒细胞中突触传递异常，表明NPTX1对维持正常运动协调功能至关重要。
**提示**：以上为模拟摘要，实际文献需通过 **PubMed/Google Scholar** 检索关键词(如"NPTX1 antibody" + "specific topic")获取全文。
The NPTX1 antibody is a tool used to detect neuronal pentraxin 1 (NPTX1), a protein belonging to the pentraxin family, which is involved in synaptic plasticity and neural communication. NPTX1. primarily expressed in the central nervous system, plays a role in recruiting AMPA receptors to postsynaptic sites, facilitating excitatory neurotransmission. It forms complexes with other pentraxins (e.g., NPTXR, NP1) to stabilize synaptic connections. Research using NPTX1 antibodies has highlighted its relevance in neurological disorders, including Alzheimer’s disease, schizophrenia, and autism spectrum disorders, where altered expression correlates with synaptic dysfunction.
NPTX1 antibodies are widely applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein localization, expression levels, and interactions in neural tissues or cell models. Commercial antibodies are often validated for specificity against recombinant NPTX1 or through knockout controls. Recent studies also explore NPTX1’s role beyond the brain, such as in cancer progression, where it may influence cell adhesion or metastasis. Despite its established functions, the precise mechanisms of NPTX1 in disease pathways remain under investigation, driving ongoing demand for reliable antibodies to dissect its biological and clinical significance.
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