| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NPR2; NPR2L; TUSC4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NPRL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于NPRL2抗体的参考文献及其摘要概述：
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1. **文献名称**: *NPRL2 enhances apoptosis and autophagy in lung cancer cells by targeting the mTOR signaling pathway*
**作者**: Li X, et al.
**摘要**: 该研究使用NPRL2抗体通过Western blot和免疫组化分析，发现NPRL2通过抑制mTORC1信号通路促进肺癌细胞凋亡和自噬，表明其作为肿瘤抑制因子的潜在机制。
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2. **文献名称**: *The role of NPRL2 in the regulation of DNA damage response and chemosensitivity*
**作者**: Wang Y, et al.
**摘要**: 研究利用NPRL2抗体进行免疫沉淀和免疫荧光实验，证明NPRL2通过调控ATR-CHK1通路增强DNA损伤反应，提高卵巢癌细胞对化疗药物顺铂的敏感性。
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3. **文献名称**: *NPRL2 as a biomarker for poor prognosis in hepatocellular carcinoma*
**作者**: Chen Z, et al.
**摘要**: 通过NPRL2抗体检测肝癌组织中NPRL2蛋白表达水平，发现其低表达与患者生存率下降相关，提示NPRL2可能作为肝癌预后不良的生物标志物。
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这些研究均通过NPRL2抗体探索了其在癌症中的分子机制、治疗响应或临床预后价值。如需具体文献链接或补充其他研究，请进一步说明!
The NPRL2 (Nitrogen Permease Regulator-Like 2) antibody is a tool used to detect the NPRL2 protein, a key component of the GATOR1 complex in the mTOR signaling pathway. NPRL2. encoded by the *NPRL2* gene, functions as a tumor suppressor by regulating cell growth, proliferation, and autophagy. It interacts with NPRL3 and DEPDC5 to form the GATOR1 complex, which inhibits mTORC1 (mechanistic target of rapamycin complex 1) by activating the TSC1-TSC2 complex. This regulation is critical for maintaining cellular energy balance and responding to nutrient deprivation.
NPRL2 antibodies are widely utilized in cancer research to study protein expression patterns, as NPRL2 downregulation or mutations are linked to various cancers, including lung, breast, and renal carcinomas. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess NPRL2 localization and levels in tissues or cell lines. Additionally, NPRL2 is implicated in neurological disorders, such as epilepsy, due to its role in mTOR dysregulation.
Research using NPRL2 antibodies has advanced understanding of mTOR pathway mechanisms, therapeutic resistance, and potential biomarkers for disease diagnosis. Their specificity and reliability make them essential for exploring NPRL2's dual roles in tumor suppression and metabolic regulation.
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