| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NMT |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NMT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与NMT1抗体相关的文献摘要示例(文献信息为模拟，供参考)：
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1. **文献名称**: *"N-myristoyltransferase 1 promotes tumor progression by regulating EZH2 stability via autophagy in ovarian cancer"*
**作者**: Li Y, et al.
**摘要**: 本研究利用NMT1特异性抗体检测卵巢癌组织中NMT1蛋白表达水平，发现其高表达与患者预后不良相关。通过免疫共沉淀和Western blot分析，揭示了NMT1通过调控自噬途径影响EZH2蛋白稳定性，促进肿瘤侵袭的机制。
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2. **文献名称**: *"Development of a monoclonal antibody against human NMT1 for functional studies in HIV-1 replication"*
**作者**: Smith J, et al.
**摘要**: 作者报道了一种新型抗人NMT1单克隆抗体的开发，验证了其在ELISA、免疫荧光和免疫印迹中的高特异性。该抗体成功用于抑制NMT1介导的HIV病毒蛋白肉豆蔻酰化，证明NMT1是抗病毒治疗的潜在靶点。
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3. **文献名称**: *"NMT1 deficiency disrupts synaptic plasticity via impairing palmitoylation in Alzheimer's disease models"*
**作者**: Wang H, et al.
**摘要**: 通过NMT1抗体免疫组化分析阿尔茨海默病模型小鼠脑组织，发现NMT1表达在突触区域显著降低。研究证明NMT1缺失导致突触蛋白棕榈酰化异常，损害突触可塑性，提示其与认知功能障碍相关。
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(注：以上文献为示例，实际文献需通过PubMed/Google Scholar等平台以关键词“NMT1 antibody”或“N-myristoyltransferase 1”检索核实。)
N-Myristoyltransferase 1 (NMT1) is a ubiquitously expressed enzyme that catalyzes the transfer of myristate, a 14-carbon fatty acid, to the N-terminal glycine residue of target proteins—a post-translational modification critical for membrane association, protein-protein interactions, and cellular localization. This process regulates diverse biological processes, including signal transduction, apoptosis, and oncogenesis. Dysregulation of NMT1 has been implicated in cancer progression, neurodegenerative diseases, and viral pathogenesis, as many oncoproteins, viral proteins, and signaling molecules rely on N-myristoylation for functionality.
NMT1 antibodies are essential tools for studying the expression, localization, and activity of NMT1 in both physiological and pathological contexts. They enable detection of NMT1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its role in diseases such as colorectal cancer, glioblastoma, and Alzheimer's disease. Additionally, these antibodies support drug discovery efforts targeting NMT1. as small-molecule inhibitors are being explored for cancer and antiviral therapies. Commercial NMT1 antibodies are typically validated for specificity against conserved epitopes, though cross-reactivity with NMT2 (a closely related isoform) must be considered. Recent studies also highlight NMT1's potential as a biomarker for therapeutic resistance, emphasizing its clinical relevance. Overall, NMT1 antibodies are pivotal in unraveling the enzyme's multifaceted roles and advancing translational research. (299 words)
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