Rabbit Polyclonal RHEB Antibody

The Ras homolog enriched in brain (RHEB) antibody is a key tool for studying the RHEB protein, a small GTPase belonging to the Ras superfamily. RHEB plays a critical role in regulating cell growth, proliferation, and survival by activating the mechanistic target of rapamycin complex 1 (mTORC1), a central nutrient and energy sensor. Dysregulation of RHEB-mTORC1 signaling is implicated in cancers, metabolic disorders, and neurodegenerative diseases. RHEB antibodies are widely used in research to detect RHEB expression levels, subcellular localization, and activity in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies often target specific regions of RHEB, such as its GTP-binding domain or phosphorylation sites, enabling the study of its activation state. Commercially available RHEB antibodies are typically validated for specificity and sensitivity across species like human, mouse, and rat. Researchers rely on them to investigate RHEB's role in autophagy, cellular stress responses, and therapeutic targeting. Recent studies also explore RHEB's involvement in aging and mTOR-related pathologies, driving demand for high-quality antibodies to support mechanistic and translational research.