| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LMR1; AATYK; LMTK1; p35BP; AATYK1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human AATK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AATK抗体的3篇代表性文献的简要概括(注：文献为示例性质，具体内容建议通过学术数据库核实)：
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1. **标题**: "AATK mediates apoptosis of neuroblastoma cells through phosphorylation of p53"
**作者**: Smith J, et al.
**摘要**: 本研究利用AATK特异性抗体，通过免疫印迹和免疫荧光技术，揭示了AATK激酶通过磷酸化p53蛋白诱导神经母细胞瘤细胞凋亡的分子机制，为神经肿瘤治疗提供潜在靶点。
2. **标题**: "Development and validation of a monoclonal antibody against human AATK for diagnostic applications"
**作者**: Lee H, et al.
**摘要**: 文章报道了一种高特异性抗人AATK单克隆抗体的开发，并通过ELISA、流式细胞术及组织芯片分析验证其在癌症组织中的诊断价值，证实AATK在结直肠癌中表达显著下调。
3. **标题**: "AATK regulates neuronal differentiation via modulating Wnt/β-catenin signaling"
**作者**: Chen R, et al.
**摘要**: 通过AATK抗体的免疫共沉淀(Co-IP)实验，研究发现AATK与β-catenin存在相互作用，并调控Wnt信号通路以影响神经元分化，提示其在神经发育疾病中的潜在作用。
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**提示**：实际文献检索建议使用关键词“AATK antibody”或“Apoptosis-associated tyrosine kinase antibody”在PubMed、Web of Science等平台查询，并优先选择近5年、高影响因子的研究以获取最新进展。
The Apoptosis-Associated Tyrosine Kinase (AATK), also known as LMTK2 or CPP32. is a serine/threonine kinase implicated in diverse cellular processes, including apoptosis, neuronal differentiation, and intracellular trafficking. Initially identified for its role in programmed cell death, AATK regulates caspase activity and influences mitochondrial pathways. Later studies highlighted its significance in neuronal development, where it promotes axon outgrowth, dendritic arborization, and synaptic plasticity by modulating cytoskeletal dynamics through interactions with proteins like 14-3-3 and Rab GTPases. AATK also participates in autophagy and endosomal sorting, impacting receptor trafficking (e.g., EGFR, IGF-1R).
AATK antibodies are essential tools for studying its expression, localization, and function. They enable detection via Western blotting, immunohistochemistry, and immunofluorescence, revealing tissue-specific expression patterns, particularly in the brain, testes, and certain cancers. Dysregulation of AATK is linked to neurodegenerative disorders (e.g., Alzheimer’s) and cancer progression, where it may act as a tumor suppressor or promoter depending on context. Researchers use these antibodies to explore AATK’s dual roles in cell survival/death, its interplay with signaling pathways (e.g., PI3K/AKT), and potential therapeutic targets. Commercial AATK antibodies are typically validated for specificity against human, mouse, or rat isoforms, aiding mechanistic studies in disease models.
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