| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NGR; NOGOR |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RTN4R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RTN4R抗体的3篇参考文献示例(信息基于公开研究概括，非真实文献)：
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1. **文献名称**: "Nogo Receptor (RTN4R) Expression in Multiple Sclerosis Lesions"
**作者**: Smith A, et al.
**摘要**: 本研究利用RTN4R特异性抗体进行免疫组化分析，发现多发性硬化症患者脑组织中RTN4R表达显著上调，且与髓鞘再生抑制相关，提示其在神经修复中的潜在调控作用。
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2. **文献名称**: "RTN4R Antibody-Based Blockade Enhances Axonal Regeneration in Spinal Cord Injury"
**作者**: Chen L, et al.
**摘要**: 通过RTN4R中和抗体阻断Nogo受体功能，实验显示脊髓损伤模型中小鼠轴突再生能力增强，证明RTN4R抗体在促进神经再生中的治疗潜力。
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3. **文献名称**: "Developmental Regulation of RTN4R in the Murine Brain"
**作者**: Johnson R, et al.
**摘要**: 采用RTN4R抗体进行Western blot和免疫荧光分析，揭示了该受体在小鼠大脑发育不同阶段的动态表达模式，提示其参与突触可塑性和神经环路形成。
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4. **文献名称**: "RTN4R Antibody Screening for Autoantibody Biomarkers in Neurological Disorders"
**作者**: Wang Y, et al.
**摘要**: 研究通过RTN4R抗体检测患者血清中的自身抗体，发现部分帕金森病患者存在RTN4R自身免疫反应，为疾病诊断提供了新生物标志物方向。
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注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词如“RTN4R antibody”、“Nogo receptor antibody”获取。
The RTN4R antibody targets the Reticulon 4 Receptor (RTN4R), also known as the Nogo Receptor, a glycoprotein predominantly expressed in the central nervous system (CNS). RTN4R plays a critical role in regulating axonal growth inhibition by binding to myelin-associated inhibitors like Nogo-A, MAG, and OMgp. These interactions activate intracellular signaling pathways, such as RhoA/ROCK, which suppress neuronal regeneration and plasticity. RTN4R is structurally characterized by leucine-rich repeats and belongs to the Nogo receptor family, which includes related proteins like LINGO-1 and NgR2. Its function is closely tied to limiting CNS repair post-injury, as it stabilizes neural circuits by restricting excessive axonal sprouting.
Antibodies against RTN4R are widely used in neuroscience research to study mechanisms of neural regeneration, synaptic plasticity, and CNS injury responses. By blocking RTN4R activity, these antibodies have been shown to enhance axonal regeneration in preclinical models of spinal cord injury and stroke. Additionally, RTN4R is implicated in neurological disorders such as Alzheimer's disease and multiple sclerosis, where its aberrant signaling may contribute to neurodegeneration. Research tools targeting RTN4R, including neutralizing antibodies, remain vital for exploring therapeutic strategies to overcome myelin-mediated inhibition and promote functional recovery in CNS pathologies.
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