| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PERC; ERRL1; PGC1B; PGC-1(beta) |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PPARGC1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PPARGC1B抗体的参考文献概览(基于公开研究数据模拟整理)：
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1. **文献名称**: "PPARGC1B regulates mitochondrial metabolism and insulin sensitivity in human adipocytes"
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性PPARGC1B抗体进行Western blot分析，发现PPARGC1B通过调控线粒体生物合成基因表达影响脂肪细胞胰岛素敏感性，为代谢综合征机制提供新证据。
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2. **文献名称**: "A PPARGC1B variant promotes prostate cancer metastasis via HIF-1α activation"
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(使用商业化PPARGC1B抗体)和基因敲除实验，揭示PPARGC1B基因变异通过HIF-1α通路促进前列腺癌转移，提示其作为癌症治疗靶点的潜力。
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3. **文献名称**: "Tissue-specific expression of PPARGC1B in obesity and its association with metabolic inflammation"
**作者**: Gonzalez-Rodriguez M, et al.
**摘要**: 采用定量PCR和PPARGC1B抗体进行蛋白检测，发现肥胖患者肝脏和骨骼肌中PPARGC1B表达显著下调，且与炎症因子水平呈负相关，提示其在代谢调控中的组织特异性作用。
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注：以上为模拟文献案例，实际引用时需通过PubMed、Web of Science等平台检索真实文献，建议结合关键词"PPARGC1B antibody"及研究领域筛选。
The PPARGC1B antibody is a crucial tool for studying the peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B), a transcriptional coactivator involved in regulating energy metabolism, mitochondrial biogenesis, and adaptive thermogenesis. PPARGC1B, also known as PGC-1β, shares structural and functional similarities with PPARGC1A (PGC-1α) and interacts with nuclear receptors and transcription factors to modulate gene expression in response to metabolic demands. It plays a key role in lipid metabolism, oxidative phosphorylation, and cellular responses to stressors like cold exposure or exercise.
PPARGC1B antibodies are widely used in research to detect and quantify the protein’s expression in tissues such as skeletal muscle, liver, and adipose tissue. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to explore PPARGC1B’s regulatory mechanisms in metabolic diseases (e.g., obesity, diabetes), cancer, and cardiovascular disorders. These antibodies are often validated for specificity using knockout models or siRNA-mediated knockdown to ensure accurate detection.
Research utilizing PPARGC1B antibodies has highlighted its role in mitochondrial dysfunction, insulin resistance, and aging. Commercially available antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein’s N- or C-terminal regions. Proper validation is essential, as cross-reactivity with PPARGC1A or other homologous proteins may occur. Overall, PPARGC1B antibodies are vital for dissecting metabolic pathways and developing therapeutic strategies targeting energy homeostasis.
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