| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2 |
| WB Predicted band size | 91 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PDE4D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PDE4D抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **"PDE4D-Specific Antibodies Reveal Subcellular Localization in Neuronal Cells"**
*作者：Smith J, et al. (2022)*
*摘要*：研究利用新型PDE4D抗体，通过免疫荧光和Western blotting技术，揭示了PDE4D亚型在神经元中的特异性分布及其与突触可塑性的关联。
2. **"Targeting PDE4D in Chronic Inflammation: Antibody-Based Inhibition Studies"**
*作者：Li X, et al. (2021)*
*摘要*：开发了高选择性PDE4D单克隆抗体，验证其在抑制炎症因子释放中的作用，为治疗类风湿性关节炎等炎症疾病提供实验依据。
3. **"PDE4D Antibody Application in Alzheimer's Disease Models"**
*作者：Garcia R, et al. (2020)*
*摘要*：通过PDE4D抗体标记，发现阿尔茨海默病模型中PDE4D表达上调，提示其可能通过调控cAMP信号通路影响神经退行性病变进程。
4. **"Characterization of PDE4D Isoforms Using Monoclonal Antibodies"**
*作者：Wang Y, et al. (2019)*
*摘要*：报道了针对PDE4D不同异构体的特异性抗体开发，并应用于癌症细胞系中PDE4D异构体表达差异的分析。
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**说明**：以上文献为示例，实际研究中请通过学术数据库(如PubMed、Google Scholar)搜索关键词“PDE4D antibody”或“PDE4D function”获取真实文献。
**Background of PDE4D Antibodies**
Phosphodiesterase 4D (PDE4D) is a member of the PDE4 enzyme family, which hydrolyzes cyclic adenosine monophosphate (cAMP), a critical secondary messenger regulating cellular signaling pathways. PDE4D is particularly notable for its role in modulating inflammation, neuronal function, and immune responses. It is expressed in various tissues, including the brain, lungs, and immune cells, and exists as multiple isoforms due to alternative splicing, enabling functional diversity. Dysregulation of PDE4D has been implicated in neuropsychiatric disorders (e.g., schizophrenia, Alzheimer’s disease), chronic obstructive pulmonary disease (COPD), and asthma, making it a therapeutic target of interest.
PDE4D-specific antibodies are essential tools for studying its expression, localization, and activity in biological systems. They enable researchers to detect PDE4D protein levels via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding in the exploration of its role in disease mechanisms. Additionally, these antibodies are used to validate PDE4D as a target in drug discovery, particularly for developing PDE4 inhibitors with potential anti-inflammatory or neuroprotective effects.
Recent studies highlight PDE4D's interaction with signaling pathways like β-adrenergic and cAMP-dependent pathways, further emphasizing its therapeutic relevance. However, challenges remain in isoform-specific targeting due to structural similarities within the PDE4 family. Advances in antibody engineering, including monoclonal and phospho-specific antibodies, continue to enhance specificity and utility in both research and clinical contexts. Overall, PDE4D antibodies bridge basic research and translational applications, offering insights into disease biology and therapeutic development.
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