Rabbit Polyclonal PHKG2 Antibody

The PHKG2 (Phosphorylase Kinase Gamma 2) antibody is a tool used to study the gamma-2 regulatory subunit of phosphorylase kinase (PhK), a key enzyme in glycogen metabolism. PHKG2. encoded by the *PHKG2* gene, is part of the heterotetrameric PhK complex (αβγδ), which activates glycogen phosphorylase to mobilize glucose from glycogen. Unlike the gamma-1 subunit (PHKG1), which is muscle-specific, PHKG2 is primarily expressed in the liver and testis, playing a critical role in regulating hepatic glycogenolysis. Mutations in *PHKG2* are linked to glycogen storage disease type 9C (GSD9C), characterized by hepatomegaly, hypoglycemia, and growth retardation. Research on PHKG2 also explores its potential involvement in cancer, as dysregulated glycogen metabolism is observed in tumors. The PHKG2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and post-translational modifications. Its specificity aids in distinguishing PHKG2 from other PhK subunits, enabling studies on tissue-specific metabolic regulation and disease mechanisms. Commercial antibodies are typically validated for cross-reactivity and target affinity, ensuring reliability in experimental models ranging from cell lines to tissue samples. Understanding PHKG2's function through antibody-based assays contributes to insights into metabolic disorders and therapeutic targeting.