| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | IFP1; RNF21 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRIM34 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM34抗体的3篇参考文献摘要，供参考：
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1. **"TRIM34 attenuates HIV-1 proviral transcription sensitivity through antagonizing SUV39H1"**
*作者：Li Y, et al. (2021)*
摘要：本研究探讨了TRIM34在HIV-1感染中的调控作用，发现其通过抑制组蛋白甲基转移酶SUV39H1.降低病毒前体DNA的转录活性。实验中利用TRIM34特异性抗体进行免疫共沉淀(Co-IP)，验证了其与SUV39H1的相互作用，为抗病毒治疗提供了新靶点。
2. **"TRIM34 promotes type I interferon-induced antiviral response through ubiquitination of TBK1"**
*作者：Zhang Q, et al. (2019)*
摘要：研究揭示了TRIM34在I型干扰素信号通路中的关键作用，证明其通过K63泛素化修饰激酶TBK1增强抗病毒免疫反应。Western blot和免疫荧光实验使用TRIM34抗体确认其在病毒感染后的亚细胞定位及表达动态变化。
3. **"Differential expression and function of TRIM family proteins in colorectal cancer"**
*作者：Wang H, et al. (2018)*
摘要：该研究通过免疫组化(IHC)和流式细胞术分析了TRIM家族蛋白在结直肠癌中的表达差异，发现TRIM34的高表达与患者生存率负相关。TRIM34抗体用于组织样本检测，证实其可作为潜在预后标志物。
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注：以上文献信息为模拟示例，实际引用时需核实具体来源及细节。如需进一步扩展或查找原文，建议通过PubMed或Google Scholar检索关键词“TRIM34 antibody”或“TRIM34 function”。
The TRIM34 antibody is a research tool used to detect and study TRIM34 (Tripartite Motif-containing protein 34), a member of the TRIM protein family. TRIM proteins are characterized by conserved RING, B-box, and coiled-coil domains, which mediate diverse cellular functions, including innate immunity, antiviral defense, and protein ubiquitination. TRIM34. encoded by the TRIM34 gene in humans, shares structural homology with other TRIM family members like TRIM5α and TRIM22. and is implicated in modulating immune responses, particularly in interferon signaling pathways. It exhibits E3 ubiquitin ligase activity, suggesting a role in post-translational protein modification and regulation of immune-related pathways.
Research using TRIM34 antibodies has highlighted its involvement in antiviral mechanisms, including potential inhibition of HIV-1 replication through interactions with viral capsid proteins. TRIM34 may also synergize with TRIM5α to enhance restriction of retroviral infections. Additionally, studies suggest its role in regulating inflammasome activation and cytokine production, linking it to autoimmune and inflammatory diseases. The antibody is essential for detecting TRIM34 expression in various cell types, analyzing its subcellular localization, and exploring protein-protein interactions in both physiological and pathological contexts. Its applications span immunoblotting, immunofluorescence, and immunoprecipitation, aiding in elucidating TRIM34's functional mechanisms in health and disease.
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