| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SMG; SMGA; SAMD4; SMAUG; SMAUG1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SAMD4A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于SAMD4A抗体的虚构参考文献示例(仅供学术写作参考，非真实文献)：
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1. **文献名称**: "SAMD4A Antibody Validation in Breast Cancer Cell Lines"
**作者**: Li et al. (2022)
**摘要**: 本研究利用SAMD4A特异性抗体，通过Western blot和免疫组化验证其在乳腺癌细胞中的表达差异，发现SAMD4A高表达与肿瘤侵袭性相关，提示其可能作为预后标志物。
2. **文献名称**: "Role of SAMD4A in Neuronal RNA Granules: An Antibody-Based Study"
**作者**: Martinez & Chen (2020)
**摘要**: 通过免疫荧光共定位实验(使用SAMD4A抗体)，揭示了SAMD4A蛋白在神经元RNA颗粒中的定位，表明其在突触可塑性和神经退行性疾病中的潜在调控作用。
3. **文献名称**: "Development of a High-Affinity SAMD4A Monoclonal Antibody for Functional Assays"
**作者**: Wang et al. (2019)
**摘要**: 报道了一种新型SAMD4A单克隆抗体的开发，验证其特异性并通过免疫沉淀技术证明SAMD4A与microRNA调控复合物的相互作用，为RNA代谢研究提供工具。
4. **文献名称**: "SAMD4A Knockout Mice Model and Antibody-Based Phenotypic Analysis"
**作者**: Gupta et al. (2021)
**摘要**: 利用SAMD4A抗体对基因敲除小鼠模型进行组织表达分析，发现SAMD4A缺失导致胚胎发育异常，强调其在细胞周期停滞中的关键功能。
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注：以上文献为模拟生成，实际研究中请通过PubMed或Google Scholar检索真实文献。
The SAMD4A (Sterile Alpha Motif Domain-containing protein 4A) antibody is a research tool used to detect and study the SAMD4A protein, a member of the SAMD family implicated in RNA metabolism and post-transcriptional regulation. SAMD4A contains a sterile alpha motif (SAM) domain, which facilitates protein-protein interactions, and is involved in cellular processes such as mRNA stability, translation, and stress granule formation. It plays roles in cell proliferation, differentiation, and apoptosis, with emerging links to cancers, neurological disorders, and viral infections.
SAMD4A antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SAMD4A expression, localization, and interactions. Studies using these antibodies have revealed SAMD4A's function as an RNA-binding protein that regulates specific mRNA targets, including those controlling cell cycle progression and stress responses. Dysregulation of SAMD4A has been observed in tumors, where it may act as a tumor suppressor or promoter depending on context, and in neurodegenerative conditions like Alzheimer’s disease, where it influences pathogenic protein aggregation.
Validated SAMD4A antibodies are critical for elucidating its molecular mechanisms and therapeutic potential. Knockout cell lines and siRNA experiments often complement antibody-based approaches to confirm target specificity. Ongoing research aims to clarify SAMD4A's role in disease pathways and its utility as a diagnostic or therapeutic biomarker.
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