| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HIN1; HIN-1; LU105; UGRP2; PnSP-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SCGB3A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SCGB3A1抗体的参考文献示例(内容为假设性示例，实际文献需通过数据库验证)：
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1. **文献名称**: *"Secretoglobin 3A1 (SCGB3A1) as a Marker of Airway Epithelial Differentiation"*
**作者**: Kurotani R, et al.
**摘要**: 本研究利用SCGB3A1特异性抗体，通过免疫组化技术定位SCGB3A1蛋白在小鼠呼吸道纤毛上皮细胞中的表达，证实其在黏膜防御和分化中的潜在作用。
2. **文献名称**: *"SCGB3A1 Expression in Lung Adenocarcinoma: Prognostic Implications"*
**作者**: Niimi T, et al.
**摘要**: 通过Western blot和免疫组化分析SCGB3A1在肺癌组织中的表达水平，发现其低表达与患者生存率下降相关，提示其作为肺癌生物标志物的可能性。
3. **文献名称**: *"Developmental Regulation of SCGB3A1 in Fetal Lung Tissues"*
**作者**: Yamada K, et al.
**摘要**: 使用SCGB3A1抗体研究人类胎儿肺发育过程，发现该蛋白在妊娠中期肺泡上皮前体细胞中显著上调，可能与肺成熟相关。
4. **文献名称**: *"SCGB3A1 Antibody-Based Detection in Gastrointestinal Stromal Tumors"*
**作者**: Zhang Y, et al.
**摘要**: 通过免疫荧光和流式细胞术，揭示SCGB3A1在胃肠道间质瘤中的异常表达，提示其可能参与肿瘤微环境调控及预后评估。
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注：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以“SCGB3A1 antibody”为关键词检索。
SCGB3A1 (Secretoglobin Family 3A Member 1), also known as uteroglobin-related protein 1 (UGRP1), is a small secreted protein belonging to the secretoglobin superfamily. It is primarily expressed in epithelial cells of the respiratory tract, reproductive organs, and other mucosal surfaces. SCGB3A1 is implicated in immunomodulatory and anti-inflammatory functions, potentially regulating cellular responses to oxidative stress, tissue injury, and pathogen exposure. Its expression is influenced by hormonal signals and inflammatory cytokines, suggesting roles in maintaining mucosal homeostasis and modulating immune activity.
Antibodies targeting SCGB3A1 are critical tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as immunohistochemistry (IHC), Western blotting, and ELISA to investigate SCGB3A1’s involvement in respiratory diseases (e.g., asthma, chronic obstructive pulmonary disease, and lung fibrosis), reproductive disorders, and cancers. For instance, reduced SCGB3A1 levels have been linked to impaired lung repair mechanisms, while its overexpression in certain tumors may correlate with disease progression.
Commercial SCGB3A1 antibodies are typically developed in rabbit or mouse hosts, with validation across human and model organism tissues. Researchers prioritize antibodies with high specificity to avoid cross-reactivity with homologous secretoglobins like SCGB1A1 (uteroglobin). These reagents have advanced studies exploring SCGB3A1 as a biomarker for early disease detection or a therapeutic target for modulating inflammation and tissue remodeling pathways.
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