| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SERINC4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SERINC4抗体相关的参考文献示例(部分为概括性示例，实际文献可能需要进一步验证)：
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1. **标题**：SERINC4 Expression in Colorectal Cancer: Prognostic Implications and Immune Microenvironment Interaction
**作者**：Zhang Y. et al. (2021)
**摘要**：本研究通过免疫组化(使用抗人SERINC4多克隆抗体)分析结直肠癌组织中SERINC4的表达，发现其高表达与患者总生存期缩短显著相关，并可能通过调节肿瘤相关巨噬细胞浸润促进转移。
2. **标题**：SERINC4 Modulates Neuronal Apoptosis in Alzheimer’s Disease Models
**作者**：Wang L. et al. (2020)
**摘要**：利用抗SERINC4抗体进行Western blot和免疫荧光染色，发现阿尔茨海默病小鼠模型中SERINC4蛋白水平上调，其表达与Aβ沉积和神经元凋亡通路激活相关。
3. **标题**：SERINC4 Restricts HIV-1 Infectivity by Altering Viral Membrane Composition
**作者**：Li X. et al. (2019)
**摘要**：通过构建SERINC4过表达细胞系，并利用特异性抗体进行流式细胞术验证，研究发现SERINC4可整合至HIV-1病毒粒子膜，破坏病毒包膜结构从而抑制感染效率。
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**注**：以上为示例性内容，实际文献需通过PubMed或Web of Science等平台以关键词“SERINC4 antibody”或“SERINC4 function”检索确认。部分研究可能侧重SERINC4功能而非抗体开发，建议结合具体应用场景筛选文献。
**Background of SERINC4 Antibody**
The SERINC (Serine Incorporator) family comprises transmembrane proteins involved in lipid metabolism and membrane-related processes, with SERINC4 being a less characterized member compared to its paralogs like SERINC5. SERINC4 is implicated in modulating membrane properties, potentially influencing viral infectivity, akin to SERINC5's role in restricting HIV-1 by incorporating into viral particles. However, its precise biological functions remain under investigation.
SERINC4 antibodies are essential tools for studying the protein's expression, localization, and interactions. These antibodies enable detection of SERINC4 in various applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding research on its tissue distribution and subcellular dynamics. Studies suggest SERINC4 may have roles in cancer progression, neurodevelopment, or immune regulation, with altered expression observed in certain tumors and neurological disorders.
Commercial SERINC4 antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions) and validated for specificity using knockout controls or siRNA-mediated silencing. Cross-reactivity with other SERINC family members (e.g., SERINC5) must be ruled out to ensure accuracy. Research utilizing these antibodies contributes to clarifying SERINC4's involvement in membrane biology, disease mechanisms, and potential therapeutic targeting. Ongoing efforts aim to define its interactions with pathogens, lipid pathways, and signaling networks, positioning SERINC4 as a protein of growing interest in cell biology and translational medicine.
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