| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PA26; SEST1 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SESN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SESN1抗体的3篇参考文献及其摘要内容：
1. **"SESN1 regulates autophagy and oxidative stress by modulating mTORC1 signaling"**
- **作者**: Lee, J.H., et al.
- **摘要**: 本研究利用SESN1特异性抗体验证其在细胞自噬中的作用，发现SESN1通过抑制mTORC1通路调控氧化应激下的自噬激活，提示其在代谢疾病中的潜在治疗价值。
2. **"Sestrin1 antibody reveals tissue-specific expression patterns in cancer progression"**
- **作者**: Chen, Y., et al.
- **摘要**: 通过免疫组化和Western blot分析，发现SESN1在多种癌症组织中高表达，其水平与患者预后相关，抗体特异性验证支持其作为癌症生物标志物的可能性。
3. **"SESN1-mediated AMPK activation protects against mitochondrial dysfunction"**
- **作者**: Kim, M., & Park, S.
- **摘要**: 使用SESN1抗体研究其在神经元中的定位，发现SESN1通过激活AMPK通路减轻线粒体损伤，为神经退行性疾病机制提供了新见解。
(注：以上文献信息为模拟示例，实际引用需查询具体数据库如PubMed或Google Scholar。)
**Background of SESN1 Antibody**
Sestrin1 (SESN1) is a stress-inducible protein belonging to the sestrin family, which includes SESN2 and SESN3. It plays a critical role in cellular responses to oxidative stress, DNA damage, and hypoxia. SESN1 acts as an antioxidant by regenerating peroxiredoxins, enzymes that neutralize reactive oxygen species (ROS), thereby protecting cells from oxidative damage. Additionally, SESN1 regulates metabolic homeostasis through modulation of the AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) pathways, influencing processes like autophagy, cell proliferation, and energy metabolism.
Studies highlight SESN1's involvement in tumor suppression, as its expression is often downregulated in cancers, correlating with poor prognosis. It also contributes to lifespan regulation and age-related pathologies, including neurodegenerative and metabolic diseases. The SESN1 antibody is a vital tool for detecting and quantifying SESN1 protein levels in techniques like Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to explore SESN1's expression patterns, subcellular localization, and interactions under physiological or pathological conditions, such as cancer progression or oxidative stress models. Validated for specificity and sensitivity, SESN1 antibodies facilitate mechanistic insights into its roles in stress adaptation, metabolic regulation, and disease, making them essential for both basic and translational research.
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