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Rabbit Polyclonal SGPL1 Antibody

  • 中文名: SGPL1抗体
  • 别    名: SPL; S1PL
货号: IPDX12164
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

参考文献

以下是关于SGPL1抗体的3篇参考文献示例(注:文献信息为示例,可能需根据实际研究调整):

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1. **文献名称**:*"SGPL1 regulates sphingolipid metabolism and endoplasmic reticulum stress in hepatic cells"*

**作者**:Chen Y, et al.

**摘要**:研究利用SGPL1特异性抗体通过Western blot和免疫荧光技术,揭示SGPL1在调节肝细胞鞘脂代谢及内质网应激中的作用,抗体验证了基因敲除模型中的蛋白表达缺失。

2. **文献名称**:*"A monoclonal antibody targeting SGPL1 for detection of lymphangiogenesis in tumors"*

**作者**:Martinez S, et al.

**摘要**:开发了一种高特异性抗人SGPL1单克隆抗体,应用于免疫组化和流式细胞术,证明SGPL1在肿瘤淋巴管生成中的表达上调,提示其作为生物标志物的潜力。

3. **文献名称**:*"SGPL1 deficiency disrupts adrenal steroidogenesis: Insights from immunohistochemical analysis"*

**作者**:Prasad R, et al.

**摘要**:通过SGPL1抗体对肾上腺组织进行免疫组化分析,发现SGPL1缺陷患者的酶表达缺失与类固醇合成障碍直接相关,为原发性肾上腺功能不全提供机制解释。

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如需真实文献,建议通过PubMed或Google Scholar搜索关键词“SGPL1 antibody”或“SGPL1 immunohistochemistry”获取最新研究。

背景信息

The SGPL1 (sphingosine-1-phosphate lyase 1) antibody is a tool used to study the enzyme encoded by the *SGPL1* gene, which plays a critical role in sphingolipid metabolism. SGPL1 catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P), a bioactive lipid involved in cellular processes like proliferation, apoptosis, and immune regulation. Dysregulation of SGPL1 is linked to diseases such as steroid-resistant nephrotic syndrome, primary adrenal insufficiency, and neurological disorders. The antibody detects SGPL1 protein expression in various tissues, aiding research into its function and distribution. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore SGPL1's role in health and disease. Studies also utilize the antibody to investigate therapeutic strategies targeting the S1P pathway in cancer, autoimmune conditions, and metabolic disorders.

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