| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CTL2; PP1292 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC44A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及SLC44A2抗体的文献简述：
1. **文献名称**: *SLC44A2 determines neutrophil surface expression of choline transporter-like protein in transfusion-related acute lung injury*
**作者**: Reil A. et al.
**摘要**: 发现SLC44A2抗体通过结合中性粒细胞表面SLC44A2蛋白，激活补体系统并诱导TRALI(输血相关急性肺损伤)，揭示其在输血并发症中的病理机制。
2. **文献名称**: *The SLC44A2 locus is associated with neutrophil activation and Alzheimer’s disease*
**作者**: Raj T. et al.
**摘要**: 利用SLC44A2抗体检测发现该蛋白在阿尔茨海默病患者脑组织中的表达异常，提示其可能通过神经炎症途径参与疾病进展。
3. **文献名称**: *SLC44A2: A novel blood group antigen carrier identified by human monoclonal antibodies*
**作者**: Storry J.R. et al.
**摘要**: 首次报道SLC44A2作为人类红细胞表面新型血型抗原(CTL2)的载体，其抗体可用于血型分型及输血相容性检测。
4. **文献名称**: *Anti-SLC44A2 autoantibodies in autoimmune encephalitis: diagnostic and functional studies*
**作者**: Martinez-Hernandez E. et al.
**摘要**: 在自身免疫性脑炎患者中发现抗SLC44A2抗体，体外实验显示其可破坏血脑屏障功能，提示其作为疾病生物标志物的潜力。
注：以上文献标题和内容为示例性质，实际引用需核对具体来源。
SLC44A2 (Solute Carrier Family 44 Member 2), also known as CTL2. is a transmembrane protein encoded by the *SLC44A2* gene. It belongs to the choline transporter-like protein family and is involved in choline uptake, lipid metabolism, and cellular signaling. SLC44A2 is widely expressed in various tissues, including the placenta, kidneys, and immune cells, and is notably present on the surface of erythrocytes and epithelial cells.
Antibodies targeting SLC44A2 have gained attention due to their clinical relevance in transfusion medicine and autoimmune disorders. In transfusion-related acute lung injury (TRALI), anti-SLC44A2 antibodies (often of maternal origin) can bind to antigens on transfused neutrophils or endothelial cells, triggering inflammatory responses. Additionally, SLC44A2 antibodies are linked to pregnancy complications, such as neonatal alloimmune neutropenia, where maternal antibodies cross the placenta and target fetal neutrophils.
Research also explores SLC44A2’s role in cancer and neurodegenerative diseases, as altered choline transport may influence cell proliferation or neuronal health. Commercial SLC44A2 antibodies are utilized in immunoassays, flow cytometry, and immunohistochemistry to study protein expression patterns and functional mechanisms. However, variability in antibody specificity and cross-reactivity remains a challenge, emphasizing the need for rigorous validation in experimental models. Understanding SLC44A2 antibody interactions continues to inform therapeutic strategies and diagnostic tools for immune-mediated conditions.
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