Rabbit Polyclonal SMARCA2 Antibody

The SMARCA2 antibody is a tool used to detect the SMARCA2 protein, a key component of the SWI/SNF chromatin-remodeling complex. SMARCA2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2), also known as BRM, plays a critical role in regulating gene expression by altering chromatin structure to facilitate transcriptional activation or repression. It is involved in diverse cellular processes, including differentiation, proliferation, and DNA repair. Dysregulation of SMARCA2 has been linked to cancers, as mutations or reduced expression are observed in certain tumors, contributing to oncogenesis or therapy resistance. SMARCA2 antibodies are widely used in research to study its expression patterns, subcellular localization, and functional interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are essential for investigating SMARCA2's role in chromatin remodeling, its interplay with tumor suppressor pathways (e.g., p53), and potential therapeutic targets. Validation of SMARCA2 antibodies typically includes testing in knockout cell lines or tissues to confirm specificity. Researchers also utilize them to explore SMARCA2's paralogous relationship with SMARCA4 (BRG1), as these proteins exhibit both overlapping and distinct roles in chromatin regulation. Their application extends to clinical studies, assessing SMARCA2 as a biomarker in cancer prognosis or treatment response.