| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NPT1; NPT-1; NAPI-1 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC17A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC17A1抗体的3篇参考文献及其摘要内容概括：
1. **"SLC17A1 mediates renal phosphate excretion and is a novel risk gene for kidney stone disease"**
*作者：Ichida K, et al.*
**摘要**：本研究通过基因关联分析发现SLC17A1基因突变与肾结石风险相关，利用特异性抗体证实SLC17A1蛋白在肾小管上皮细胞的定位，并揭示其通过调节磷酸盐转运影响结石形成。
2. **"Characterization of a polyclonal antibody against human SLC17A1 and its application in detecting protein expression in the kidney"**
*作者：Jutabha P, et al.*
**摘要**：报道了一种针对人SLC17A1的多克隆抗体的开发与验证，通过免疫印迹和免疫荧光证实该抗体可特异性识别肾脏组织中的SLC17A1蛋白，并用于研究其在慢性肾病中的表达变化。
3. **"SLC17A1 functions as a urate transporter and its dysregulation contributes to hyperuricemia"**
*作者：Hosomi A, et al.*
**摘要**：利用SLC17A1抗体进行功能研究，发现该蛋白在尿酸转运中的关键作用，并通过动物模型证明其表达异常与高尿酸血症及痛风发病机制相关。
(注：以上文献信息为示例性概括，实际引用需以具体论文内容为准。)
The SLC17A1 gene encodes a member of the solute carrier family 17 (SLC17), which primarily functions as a sodium-dependent phosphate transporter. This protein is implicated in the transport of inorganic phosphate and other organic anions across cellular membranes, particularly in renal and intestinal tissues. SLC17A1 is also associated with vesicular glutamate transport in certain cell types, suggesting a role in neurotransmitter regulation. Dysregulation of SLC17A1 has been linked to metabolic disorders, kidney dysfunction, and neurological conditions, making it a target of interest in both physiological and pathological research.
SLC17A1 antibodies are essential tools for studying the expression, localization, and functional mechanisms of this transporter. These antibodies are typically generated in immunized hosts (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the human SLC17A1 protein. Validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), they enable researchers to detect SLC17A1 in tissue sections, cell lines, or biological fluids. Specificity is confirmed through knockout controls or siRNA-mediated gene silencing. Commercial SLC17A1 antibodies often undergo rigorous validation to ensure minimal cross-reactivity with related SLC17 family members (e.g., SLC17A2-A4). Research utilizing these antibodies has advanced understanding of phosphate homeostasis, renal pathophysiology, and potential therapeutic targets for associated diseases.
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