| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OATPB; OATP-B; OATP2B1; SLC21A9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLCO2B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLCO2B1抗体的3篇参考文献摘要概览：
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1. **文献名称**：*SLCO2B1 Expression and Function in Prostate Cancer Cell Growth*
**作者**：Yang M, et al.
**摘要**：研究利用SLCO2B1特异性抗体发现其在去势抵抗性前列腺癌细胞中高表达，抗体阻断实验表明SLCO2B1可能通过介导胆固醇摄取促进癌细胞增殖，提示其作为治疗靶点的潜力。
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2. **文献名称**：*SLCO2B1 as a Predictor of Statin Pharmacokinetics*
**作者**：DeGorter MK, et al.
**摘要**：通过免疫组化(使用SLCO2B1抗体)分析肠道组织，证实该转运蛋白影响他汀类药物的肠道吸收效率，抗体检测结果为个体化用药剂量提供分子依据。
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3. **文献名称**：*SLCO2B1 Antibody Validation in Colorectal Cancer Biomarker Discovery*
**作者**：Chen Z, et al.
**摘要**：研究验证了一种高特异性SLCO2B1抗体的可靠性，发现SLCO2B1在结直肠癌组织中的表达与患者生存率负相关，提示其作为预后生物标志物的可能性。
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**备注**：以上为简化示例，实际文献需通过PubMed/Google Scholar检索关键词“SLCO2B1 antibody”或“SLCO2B1 transporter”获取。近年研究多聚焦于该蛋白在肿瘤耐药性及药物代谢中的作用。
The SLCO2B1 gene encodes the organic anion-transporting polypeptide 2B1 (OATP2B1), a membrane transporter protein belonging to the solute carrier (SLC) superfamily. Expressed in tissues such as the liver, intestine, placenta, and prostate, OATP2B1 facilitates the cellular uptake of various endogenous compounds (e.g., steroid hormones, prostaglandins) and xenobiotics, including statins, antihistamines, and anticancer drugs. Its role in drug absorption, distribution, and metabolism has made it a focus in pharmacokinetic studies, particularly regarding drug-drug interactions and interindividual variability in therapeutic responses.
SLCO2B1 antibodies are immunological tools developed to detect and quantify OATP2B1 expression in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific localization, protein regulation, and disease associations. For instance, altered OATP2B1 expression has been implicated in hormone-dependent cancers (e.g., prostate and breast cancer), where it may influence steroid hormone uptake and tumor progression. Additionally, SLCO2B1 antibodies help investigate transporter-mediated drug resistance or toxicity in preclinical models. Validation of these antibodies is critical, as nonspecific binding or cross-reactivity with other OATP isoforms can affect data reliability. Researchers prioritize antibodies with demonstrated specificity through knockout controls or siRNA-based silencing. Overall, SLCO2B1 antibodies serve as essential reagents for unraveling the transporter’s physiological roles and its implications in disease and drug therapy.
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