| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VPS5; HsT17379 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SNX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX1抗体的3篇参考文献的简要信息：
1. **文献名称**：*"Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection"*
**作者**：Bujny, M.V., et al.
**摘要**：该研究利用SNX1抗体通过免疫荧光技术，揭示了SNX1蛋白在沙门氏菌感染过程中参与宿主细胞空泡重塑的早期阶段，表明其在细胞内病原体清除中的作用。
2. **文献名称**：*"Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the Sorting Nexins"*
**作者**：Rojas, R., et al.
**摘要**：通过Western blot和免疫沉淀实验结合SNX1抗体，研究发现SNX1与逆转运复合体(retromer)相互作用，调控内体到高尔基体的逆向运输，影响膜蛋白分选。
3. **文献名称**：*"SNX1 links endosomal trafficking to the invasion process of Listeria monocytogenes"*
**作者**：Pizarro-Cerdá, J., et al.
**摘要**：该文献使用SNX1抗体进行功能抑制实验，证明SNX1通过调控内体膜动力学影响单核细胞增生李斯特菌的入侵能力，揭示了其在宿主-病原体互作中的关键角色。
(注：以上文献信息为示例性质，具体内容请以实际论文为准。)
SNX1 (Sorting Nexin 1) is a member of the sorting nexin family, a group of proteins involved in membrane trafficking, endosomal sorting, and cellular signaling. These proteins typically contain a phox homology (PX) domain that facilitates binding to phosphoinositides, enabling their association with lipid membranes. SNX1 plays a critical role in endosomal sorting, particularly in the retromer-mediated retrieval of cargo proteins (e.g., cation-independent mannose 6-phosphate receptor) from endosomes to the trans-Golgi network. It also participates in regulating endosome-to-plasma membrane trafficking and autophagy processes. Dysregulation of SNX1 has been linked to neurodegenerative diseases, cancer, and metabolic disorders, highlighting its importance in cellular homeostasis.
SNX1 antibodies are essential tools for studying these functions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect SNX1 expression, localization, and interactions in various biological contexts. Researchers employ these antibodies to investigate SNX1's role in receptor recycling, endosomal dynamics, and disease mechanisms. Many commercial SNX1 antibodies are raised against specific epitopes, often within the PX or coiled-coil domains, and their specificity is validated across human, mouse, and rat models. Studies utilizing SNX1 antibodies have advanced understanding of intracellular trafficking pathways and their implications in health and disease.
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