Rabbit Polyclonal SNX2 Antibody

The SNX2 antibody is a crucial tool for studying Sorting Nexin 2 (SNX2), a member of the sorting nexin family involved in intracellular membrane trafficking, endosomal sorting, and cellular signaling. SNX2 contains a Phox homology (PX) domain, enabling lipid-binding and membrane association, and a Bin-Amphiphysin-Rvs (BAR) domain, which facilitates membrane curvature sensing. These features allow SNX2 to participate in endosome-to-Golgi retrieval pathways, receptor recycling, and autophagosome formation. SNX2 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect SNX2 expression, localization, and interactions in various cell types or tissues. Research has linked SNX2 dysregulation to diseases such as cancer, neurodegenerative disorders (e.g., Alzheimer’s), and viral infections, where it may influence pathogen entry or immune responses. Antibodies targeting specific SNX2 epitopes (e.g., N-terminal, C-terminal, or post-translational modification sites) help dissect its functional roles in health and disease. Commercial SNX2 antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls, and optimized for cross-reactivity in human, mouse, or rat models. Their applications span basic research in cell biology, biomarker discovery, and therapeutic target validation.