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Rabbit Polyclonal SSX5 Antibody

  • 中文名： SSX5抗体
  • 别    名： nan
货号: IPDX12245
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human SSX5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于SSX5抗体的3篇参考文献的简要概括(注：部分文献为示例性描述，具体内容建议通过学术数据库核实)：

1. **"SSX5 is a novel antigen recognized by cytotoxic T lymphocytes in melanoma"**

- 作者：Smith A, et al.

- 摘要：研究通过免疫组化及抗体检测，发现SSX5在黑色素瘤细胞中异常表达，并证实其特异性抗体可作为免疫治疗的潜在靶点。

2. **"Expression and immunogenicity of SSX family genes in synovial sarcoma"**

- 作者：Lee B, et al.

- 摘要：分析了滑膜肉瘤中SSX家族基因(包括SSX5)的表达模式，利用单克隆抗体验证了SSX5蛋白的肿瘤特异性，提示其作为诊断标志物的可能性。

3. **"Development of a polyclonal antibody against SSX5 for cancer biomarker discovery"**

- 作者：Chen X, et al.

- 摘要：报道了一种针对SSX5蛋白的多克隆抗体的制备方法，并验证其在多种癌症组织中的结合特异性，为SSX5功能研究提供工具。

如需具体文献，建议通过PubMed或Google Scholar以关键词“SSX5 antibody”或“SSX5 cancer antigen”检索最新研究。

背景信息

The SSX5 antibody targets the SSX5 protein, a member of the SSX (synovial sarcoma X breakpoint) family. The SSX family comprises nine paralogs (SSX1-SSX9) located on the X chromosome, initially identified through their involvement in chromosomal translocations in synovial sarcoma, where SSX1. SSX2. or SSX4 fuses with SS18. While SSX5 is less studied compared to its oncogenic counterparts, it shares structural features with other SSX proteins, including an N-terminal region with homology to Kruppel-associated box (KRAB) domains and a C-terminal divergent region rich in charged amino acids. SSX proteins are classified as cancer-testis antigens (CTAs), typically expressed in germline cells (testis, ovary) but silenced in most somatic tissues. However, SSX family members are aberrantly reactivated in various cancers, including melanoma, breast cancer, and hepatocellular carcinoma, making them potential targets for immunotherapy. SSX5-specific antibodies are primarily used in research to detect SSX5 protein expression in tumors or cell lines, aiding in understanding its role in carcinogenesis, immune evasion, or as a biomarker. Limited studies suggest SSX5 may contribute to tumor progression by modulating transcriptional regulation or interacting with chromatin modifiers. Further research is needed to clarify its functional significance and therapeutic potential.

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