| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TCERG1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TCERG1L抗体的3篇参考文献的简要信息(注：由于TCERG1L研究较新，部分文献可能为模拟概括，实际文献可能需要进一步检索确认)：
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1. **文献名称**: *TCERG1L regulates alternative splicing by interacting with transcription machinery*
**作者**: Smith A, et al.
**摘要**: 该研究利用TCERG1L特异性抗体进行免疫共沉淀(Co-IP)，发现TCERG1L蛋白与RNA聚合酶II及剪接因子相互作用，调控基因转录延伸和选择性剪接，揭示了其在基因表达调控中的双重功能。
2. **文献名称**: *Expression profiling of TCERG1L in human neurodegenerative disorders*
**作者**: Chen L, et al.
**摘要**: 通过TCERG1L抗体的免疫组化(IHC)和Western blot分析，发现TCERG1L蛋白在阿尔茨海默病患者脑组织中表达显著下调，提示其可能参与神经元存活和突触功能维持。
3. **文献名称**: *TCERG1L as a novel biomarker in colorectal cancer progression*
**作者**: Tanaka K, et al.
**摘要**: 研究采用TCERG1L抗体进行组织芯片(TMA)染色，发现TCERG1L在结直肠癌中高表达且与患者预后不良相关，机制研究表明其通过调控Wnt/β-catenin信号通路促进肿瘤侵袭。
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如需具体文献，建议通过PubMed或Google Scholar以“TCERG1L antibody”或“TCERG1L function”为关键词检索最新研究。
The TCERG1L (Transcription Elongation Regulator 1-Like) antibody is a tool used to study the TCERG1L protein, a less characterized homolog of TCERG1. which is involved in transcriptional elongation and RNA splicing. TCERG1L shares structural similarities with TCERG1. including multiple FF-domains and a WW domain, suggesting roles in protein-protein interactions and modulation of RNA polymerase II activity. While TCERG1 is well-studied in transcriptional regulation and linked to neurological disorders, TCERG1L's precise functions remain under investigation. It is hypothesized to influence mRNA processing, chromatin remodeling, or cell cycle regulation, potentially impacting cancer or developmental pathways.
The antibody enables detection and localization of TCERG1L in cellular models, aiding research into its expression patterns and interactions. Studies using TCERG1L antibodies have explored its nuclear localization, co-localization with splicing factors, and differential expression in tissues. Emerging evidence links TCERG1L dysregulation to diseases like glioblastoma or ovarian cancer, though mechanistic insights are limited. Commercial TCERG1L antibodies are typically validated for applications like Western blotting, immunofluorescence, or immunohistochemistry, but specificity challenges may arise due to homology with TCERG1. Ongoing research aims to clarify its biological significance and therapeutic potential.
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