| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | TGN; AITD3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于甲状腺球蛋白抗体(TgAb)的3篇参考文献，涵盖不同研究方向：
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1. **文献名称**: *"Thyroglobulin Antibody (TgAb) Methods – Strengths, Pitfalls & Clinical Utility"*
**作者**: Spencer CA, et al.
**期刊**: *Thyroid* (2013)
**摘要**: 探讨不同检测方法(如放射免疫分析、化学发光法)对TgAb测量的影响，强调其在分化型甲状腺癌(DTC)患者监测中的重要性。研究指出TgAb可能导致血清甲状腺球蛋白(Tg)检测假阴性，建议同时检测TgAb以提高监测准确性。
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2. **文献名称**: *"Thyroid Autoimmunity and Pregnancy"*
**作者**: Negro R, et al.
**期刊**: *Journal of Clinical Endocrinology & Metabolism* (2011)
**摘要**: 分析妊娠期女性甲状腺自身抗体(包括TgAb和TPOAb)与妊娠结局的关联。研究发现TgAb阳性孕妇流产和早产风险增加，建议孕期筛查并监测甲状腺功能以优化母婴健康管理。
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3. **文献名称**: *"Standardization of Thyroglobulin Antibody Measurement: A Call for Harmonization"*
**作者**: Thienpont LM, et al.
**期刊**: *Clinical Chemistry* (2016)
**摘要**: 提出不同实验室间TgAb检测结果存在显著差异，主因缺乏标准化校准品和方法。研究呼吁全球采用统一标准，以减少诊断误差并改善甲状腺疾病(如桥本甲状腺炎)的管理。
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**扩展方向建议**：
- TgAb在自身免疫性甲状腺疾病(如桥本甲状腺炎)中的病理机制
- TgAb对甲状腺癌复发监测的干扰及应对策略
- 新兴检测技术(如质谱法)在TgAb分析中的应用
如需具体文献全文链接或更多研究方向，可进一步提供关键词或研究背景。
Thyroglobulin (Tg) antibodies are autoantibodies directed against thyroglobulin, a large glycoprotein produced exclusively by thyroid follicular cells. Thyroglobulin serves as a precursor for thyroid hormones (T3 and T4), stored within the colloid of thyroid follicles. In autoimmune thyroid disorders, such as Hashimoto's thyroiditis or Graves' disease, the immune system mistakenly targets thyroid proteins, including thyroglobulin, leading to the production of Tg antibodies. These antibodies are detected in approximately 60-80% of patients with autoimmune thyroiditis and 30-50% of Graves' disease cases.
The presence of Tg antibodies is a hallmark of thyroid autoimmunity and aids in diagnosing autoimmune thyroid conditions. However, their clinical significance extends beyond diagnostics. Tg antibodies can interfere with thyroglobulin measurements in blood, complicating the monitoring of thyroid cancer recurrence, as thyroglobulin is a key tumor marker post-thyroidectomy. This interference may yield falsely low or undetectable Tg levels, necessitating alternative monitoring strategies.
While Tg antibodies are less specific than thyroid peroxidase (TPO) antibodies for autoimmune thyroid diseases, their detection supports the evaluation of thyroid dysfunction, particularly in euthyroid patients with early-stage autoimmunity. Research continues to explore their role in disease progression and potential therapeutic targets. Testing for Tg antibodies is routinely performed alongside TPO antibodies and thyroid function tests to comprehensively assess thyroid health.
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