| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ACAN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ACAN抗体的3篇参考文献示例(内容为模拟生成，供参考)：
---
1. **文献名称**: *Autoantibodies to Aggrecan G1 Domain in Rheumatoid Arthritis: Diagnostic and Clinical Significance*
**作者**: Smith A, et al.
**摘要**: 研究揭示了ACAN抗体(针对聚集蛋白聚糖G1结构域)在类风湿性关节炎(RA)患者血清中的高特异性，提出其可作为RA的潜在生物标志物，并与关节破坏程度相关。
---
2. **文献名称**: *Aggrecan Antibodies in Osteoarthritis: Role in Cartilage Degradation*
**作者**: Chen L, et al.
**摘要**: 通过动物模型和人类组织分析，发现ACAN抗体在骨关节炎(OA)中可能通过激活炎症通路加剧软骨降解，提示其参与OA病理进程。
---
3. **文献名称**: *Anti-Aggrecan Antibodies as a Novel Target for Juvenile Idiopathic Arthritis Diagnosis*
**作者**: Rodriguez M, et al.
**摘要**: 该研究开发了一种新型ELISA检测法，证明ACAN抗体在幼年特发性关节炎(JIA)患儿中显著升高，可能为早期诊断提供新方向。
---
*注：以上文献为示例性内容，实际引用需核实真实数据库(如PubMed)。*
ACAN antibodies target aggrecan, a large proteoglycan essential for the structure and function of cartilage. Aggrecan, encoded by the ACAN gene, is a core component of the extracellular matrix in articular cartilage and other connective tissues. It consists of a core protein decorated with glycosaminoglycan (GAG) chains, primarily chondroitin sulfate and keratan sulfate, which enable cartilage to resist compressive forces by retaining water. This hydration is critical for joint lubrication and shock absorption.
ACAN antibodies are widely used in research to study cartilage biology, degradation mechanisms in osteoarthritis, rheumatoid arthritis, and intervertebral disc disorders. They help detect aggrecan fragments in bodily fluids, serving as biomarkers for cartilage turnover. In developmental studies, these antibodies track aggrecan expression during chondrogenesis and skeletal maturation.
Clinically, ACAN autoantibodies are investigated in arthritis pathogenesis, where their presence may correlate with disease progression. Additionally, ACAN antibodies are tools in tissue engineering to assess cartilage regeneration in scaffolds. Common detection methods include immunohistochemistry, Western blotting, and ELISA. However, cross-reactivity with other proteoglycans requires careful validation. Understanding aggrecan’s role through ACAN antibodies remains vital for advancing therapies in cartilage-related diseases.
×
