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Rabbit Polyclonal SLC8A1 Antibody

  • 中文名: SLC8A1抗体
  • 别    名: NCX1
货号: IPDX12693
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesNCX1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human SLC8A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及SLC8A1(NCX1)抗体的研究文献示例(文献信息为模拟概括,仅供格式参考):

1. **文献名称**:*"Differential expression of sodium-calcium exchanger-1 in myocardial hypertrophy"*

**作者**:Smith A, et al.

**摘要**:通过Western blot和免疫组化技术,使用SLC8A1特异性抗体研究心肌肥厚模型中NCX1蛋白的表达变化,发现其在病理状态下表达显著上调,提示其与心脏功能异常相关。

2. **文献名称**:*"NCX1 localization in neuronal calcium signaling pathways"*

**作者**:Chen L, et al.

**摘要**:利用SLC8A1抗体进行免疫荧光染色,揭示NCX1在大脑海马神经元中的亚细胞定位,证实其在调节钙稳态和突触可塑性中的关键作用。

3. **文献名称**:*"SLC8A1 as a biomarker in colorectal cancer progression"*

**作者**:Wang X, et al.

**摘要**:通过免疫组织化学(IHC)结合SLC8A1抗体,分析结直肠癌组织中NCX1的表达水平,发现其高表达与肿瘤转移和患者预后不良显著相关。

如需具体文献,建议通过PubMed或Google Scholar检索关键词 **"SLC8A1 antibody"** 或 **"NCX1 antibody application"**,筛选实验方法中包含抗体验证(如WB/IHC)的研究。

背景信息

The SLC8A1 antibody is a research tool designed to detect the sodium-calcium exchanger 1 (NCX1), a transmembrane protein encoded by the SLC8A1 gene. NCX1 plays a critical role in maintaining intracellular calcium homeostasis by exchanging three sodium ions for one calcium ion across the plasma membrane. This exchanger is particularly vital in excitable tissues, such as the heart, where it regulates cardiac contractility by mediating calcium efflux during relaxation. Dysregulation of NCX1 has been linked to cardiovascular pathologies, including heart failure, arrhythmias, and hypertension. SLC8A1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to study NCX1 expression, localization, and function in both physiological and disease contexts. These antibodies are essential for investigating tissue-specific expression patterns, such as its high abundance in cardiac muscle, and for validating experimental models of calcium signaling disorders. Researchers also utilize SLC8A1 antibodies to explore NCX1's role in cellular responses to stress, such as ischemia-reperfusion injury, and its interaction with regulatory proteins. Validating antibody specificity via knockout controls or peptide blocking is crucial to ensure accurate detection, given the protein's structural complexity and splice variants.

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