| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human JAK3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于JAK3抗体的参考文献示例(内容基于公开研究领域知识总结，非真实文献引用)：
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1. **文献名称**：*"Development of a monoclonal antibody targeting JAK3 for autoimmune disease therapy"*
**作者**：Müller et al. (2018)
**摘要**：研究报道了一种新型抗人JAK3单克隆抗体的开发，通过阻断JAK3-STAT5信号通路抑制T细胞过度活化，在类风湿性关节炎小鼠模型中显著降低炎症反应和关节损伤。
2. **文献名称**：*"JAK3-specific antibody inhibits cytokine signaling in T-cell leukemia"*
**作者**：Jones & Patel (2015)
**摘要**：该研究利用JAK3特异性抗体选择性抑制白血病细胞中的JAK3依赖性信号传导，证明其可诱导T细胞白血病细胞凋亡，为靶向治疗JAK3突变相关血液肿瘤提供实验依据。
3. **文献名称**：*"High-affinity anti-JAK3 antibodies enhance allograft survival in murine transplant models"*
**作者**：Sato et al. (2020)
**摘要**：通过筛选获得高亲和力抗JAK3抗体，可有效抑制移植后免疫排斥反应。实验表明抗体通过干扰IL-2/IL-15受体下游信号，延长小鼠心脏移植模型的移植物存活时间。
4. **文献名称**：*"Structural characterization of JAK3 epitopes recognized by therapeutic antibodies"*
**作者**：Zhang et al. (2019)
**摘要**：通过冷冻电镜解析JAK3蛋白与治疗性抗体的复合物结构，揭示抗体结合JAK3的JH2结构域并抑制其异常激活的分子机制，为优化抗体药物设计提供结构基础。
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注：以上为模拟文献示例，实际引用需以真实发表的论文为准。建议通过PubMed或Web of Science检索关键词“JAK3 antibody”获取具体文献。
JAK3 (Janus kinase 3) is a tyrosine kinase belonging to the JAK family, which plays a crucial role in cytokine receptor signaling. Primarily expressed in hematopoietic cells, JAK3 associates with the gamma-chain (γc) of cytokine receptors, such as those for interleukins IL-2. IL-4. IL-7. IL-9. IL-15. and IL-21. Upon cytokine binding, JAK3 activates downstream signaling pathways, including STAT (signal transducer and activator of transcription) proteins, regulating immune cell development, proliferation, and function. Mutations or dysregulated JAK3 activity are linked to immune disorders, including severe combined immunodeficiency (SCID) and autoimmune diseases, as well as hematologic cancers.
JAK3-specific antibodies are vital tools for studying its expression, activation, and interactions in research. They enable detection of JAK3 protein levels (via Western blot, immunohistochemistry) and phosphorylation status (indicative of activation) in cell signaling studies. Additionally, JAK3 antibodies aid in elucidating mechanisms of JAK3-targeted therapies, such as kinase inhibitors (e.g., tofacitinib) used in autoimmune conditions like rheumatoid arthritis. These antibodies also help identify JAK3 mutations in clinical diagnostics, guiding personalized treatment strategies. Overall, JAK3 antibodies are essential for advancing both basic research and therapeutic development in immunology and oncology.
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