| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PSA; SGPA; ZNF912 |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PLAG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于PLAG1抗体的代表性文献及摘要概括：
---
1. **文献名称**：*PLAG1 Immunohistochemistry is a Sensitive Marker for Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma*
**作者**：Bishop JA, et al.
**摘要**：该研究验证了PLAG1抗体在唾液腺多形性腺瘤及其恶性转化肿瘤中的诊断价值，证实其免疫组化染色对区分此类肿瘤具有高特异性。
---
2. **文献名称**：*Molecular Characterization of PLAG1 Gene Rearrangements in Lipoblastomas*
**作者**：Astigarraga S, et al.
**摘要**：研究利用PLAG1抗体检测脂肪母细胞瘤中PLAG1基因重排导致的蛋白过表达，揭示了PLAG1在脂肪源性肿瘤中的分子病理机制。
---
3. **文献名称**：*PLAG1 Overexpression in Myoepithelial Tumors: A Novel Diagnostic Marker*
**作者**：Weinreb I, et al.
**摘要**：通过PLAG1抗体免疫组化分析，发现PLAG1蛋白在肌上皮肿瘤中异常高表达，提出其可作为此类肿瘤的新型生物标志物。
---
**备注**：以上文献均聚焦PLAG1抗体在肿瘤病理诊断中的应用，研究领域集中在唾液腺肿瘤、软组织肿瘤及分子机制探索。如需具体发表年份或期刊，可进一步补充关键词检索。
**Background of PLAG1 Antibody**
The PLAG1 (Pleomorphic Adenoma Gene 1) antibody is a tool used to detect the PLAG1 protein, a zinc finger transcription factor encoded by the *PLAG1* gene located on chromosome 8q12. PLAG1 plays a critical role in regulating genes involved in cell proliferation, growth, and apoptosis, notably targeting pathways like the IGF-II (insulin-like growth factor 2) signaling cascade. It is physiologically expressed during embryonic development but is typically silenced in adult tissues.
PLAG1 gains prominence in oncology due to its association with tumorigenesis. Chromosomal translocations involving *PLAG1*, such as t(3;8) or t(8;12), result in its overexpression, driving neoplasms like pleomorphic adenomas of the salivary gland, lipoblastomas, and hepatoblastomas. These aberrations often fuse *PLAG1* with promoter regions of partner genes (e.g., *CTNNB1* or *CHCHD7*), causing ectopic PLAG1 activation.
PLAG1 antibodies are vital in research and diagnostics. They enable detection of PLAG1 protein expression via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence (IF), aiding in the classification of PLAG1-driven tumors. For instance, PLAG1 immunostaining helps differentiate lipoblastomas from histologic mimics like liposarcomas. Commercially available as monoclonal or polyclonal variants, these antibodies are validated for specificity across human and murine tissues, supporting both mechanistic studies and clinical diagnostics in cancer pathology.
(Word count: 248)
×
