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Rabbit Polyclonal ZMYM2 Antibody

  • 中文名: ZMYM2抗体
  • 别    名: FIM; MYM; RAMP; SCLL; ZNF198
货号: IPDX12840
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesFIM; MYM; RAMP; SCLL; ZNF198
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ZMYM2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ZMYM2抗体的参考文献示例(注:文献为示例性内容,建议通过学术数据库核实真实文献):

1. **文献名称**:*ZMYM2 interacts with the NuRD complex to regulate transcriptional repression and chromatin compaction*

**作者**:Hakimi MA, et al.

**摘要**:本研究利用ZMYM2特异性抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP-seq),揭示ZMYM2与NuRD复合体相互作用,参与基因沉默和染色质结构调控,提示其在表观遗传修饰中的关键作用。

2. **文献名称**:*Functional characterization of ZMYM2 in maintaining telomeric heterochromatin integrity*

**作者**:Shi Y, et al.

**摘要**:通过CRISPR/Cas9敲除结合ZMYM2抗体的免疫荧光分析,发现ZMYM2对端粒异染色质的稳定性至关重要,抗体验证显示其在细胞核内与端粒区域共定位,影响端粒长度调控。

3. **文献名称**:*ZMYM2 is a novel biomarker for aggressive prostate cancer identified by antibody-based proteomic screening*

**作者**:Liu X, et al.

**摘要**:采用ZMYM2抗体对前列腺癌组织进行免疫组化(IHC)分析,发现ZMYM2高表达与肿瘤转移和不良预后显著相关,提示其作为潜在临床标志物的价值。

4. **文献名称**:*Structural insights into ZMYM2-FGFR1 oncogenic fusion proteins using epitope-specific antibodies*

**作者**:Park J, et al.

**摘要**:针对ZMYM2-FGFR1融合蛋白的特异性抗体被开发并用于Western blot和免疫沉淀,证实其在血液系统肿瘤中异常激活MAPK信号通路的机制。

**提示**:以上为模拟示例,实际文献请通过PubMed、Google Scholar等平台以关键词“ZMYM2 antibody”或“ZMYM2 immunohistochemistry”检索。

背景信息

The ZMYM2 antibody is a research tool designed to detect the zinc finger MYM-type containing 2 (ZMYM2) protein, also known as ZNF198 or FIM3. ZMYM2 is a multidomain protein involved in transcriptional regulation, chromatin remodeling, and epigenetic modifications. It contains tandem zinc finger motifs, enabling interactions with DNA, histones, or other proteins. Notably, ZMYM2 is a component of the CoREST complex, which partners with histone deacetylases (HDACs) and lysine-specific demethylase 1 (LSD1) to mediate gene silencing. Dysregulation of ZMYM2 is linked to diseases, including cancer, where chromosomal translocations (e.g., ZMYM2-FGFR1 in myeloid malignancies) drive oncogenic fusion proteins. Antibodies against ZMYM2 are typically developed in rabbits or mice, using immunogenic peptide sequences or recombinant protein fragments. They are validated for applications like Western blotting, immunoprecipitation, and immunofluorescence to study ZMYM2’s role in chromatin organization, DNA repair, or stem cell differentiation. Specificity is confirmed using knockout controls or siRNA knockdown. These antibodies aid in exploring ZMYM2’s interplay with pathways like TGF-β signaling and its potential as a therapeutic target.

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