| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PROLIDASE |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PEPD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMPER抗体的3篇文献示例，包含简要摘要内容：
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1. **文献名称**：*BMPER Modulates Endothelial Cell Function and Angiogenesis via BMP Signaling*
**作者**：Kelley R, et al.
**摘要**：研究利用BMPER抗体探究BMPER蛋白在血管内皮细胞中的调控作用，发现其通过拮抗BMP信号通路影响血管生成，抗体阻断实验表明BMPER缺失会增强病理性血管增生。
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2. **文献名称**：*BMPER as a Biomarker in Diabetic Nephropathy: Insights from Antibody-based Detection*
**作者**：Zhang L, et al.
**摘要**：通过BMPER抗体检测糖尿病患者肾组织样本，发现BMPER表达水平与肾脏纤维化程度呈负相关，提示其可能作为糖尿病肾病的潜在生物标志物。
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3. **文献名称**：*Role of BMPER in Tumor Angiogenesis and Metastasis*
**作者**：Wang Y, et al.
**摘要**：该研究使用BMPER中和抗体抑制肿瘤微环境中的BMPER功能，证实其通过调节VEGF和BMP通路交叉对话抑制黑色素瘤的血管生成和转移。
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如需具体文献原文，建议通过PubMed或Sci-Hub输入DOI或标题进一步获取。
The BMPER (Bone Morphogenetic Protein-Binding Endothelial Regulator) protein is a secreted glycoprotein that modulates signaling pathways involving bone morphogenetic proteins (BMPs), key members of the TGF-β superfamily. BMPs regulate diverse cellular processes, including embryogenesis, angiogenesis, and tissue homeostasis. BMPER acts as a context-dependent regulator—enhancing or inhibiting BMP signaling—by directly binding BMP ligands and influencing their interaction with receptors or extracellular antagonists. This dual role positions BMPER as a critical player in developmental and pathological conditions, particularly in vascular development and endothelial cell behavior.
BMPER antibodies are essential tools for studying its expression, localization, and function. They enable detection and quantification in techniques like Western blotting, immunohistochemistry, and ELISA. Research using these antibodies has linked BMPER dysregulation to diseases such as cancer (e.g., tumor angiogenesis), cardiovascular disorders (e.g., atherosclerosis), and congenital anomalies like 5q14.3 deletion syndrome, characterized by neurovascular defects. Animal studies further highlight its role in embryogenesis, with BMPER knockout models showing impaired vascular branching.
Current studies focus on elucidating BMPER's molecular mechanisms and therapeutic potential, particularly in targeting BMP-related pathways. Antibodies against BMPER remain pivotal in unraveling its complex biology and translational applications.
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