| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ENPP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ENPP2抗体的3篇示例文献(注：文献信息为虚拟示例，实际引用需查询数据库)：
1. **文献名称**：*Targeting ENPP2 with a novel monoclonal antibody inhibits cancer cell migration in vitro*
**作者**：Smith J, et al.
**摘要**：研究开发了一种靶向ENPP2的单克隆抗体，通过阻断其溶血磷脂酸(LPA)合成活性，显著抑制了多种癌细胞系的迁移能力，为抗转移治疗提供新策略。
2. **文献名称**：*ENPP2-neutralizing antibody reduces fibrosis in a murine model of liver injury*
**作者**：Lee H, et al.
**摘要**：在小鼠肝纤维化模型中，使用ENPP2中和抗体可降低胶原沉积和炎症因子表达，证明ENPP2抗体在纤维化疾病中的潜在治疗价值。
3. **文献名称**：*Autotaxin (ENPP2) antibody suppresses angiogenesis in triple-negative breast cancer*
**作者**：Wang Y, et al.
**摘要**：研究显示，ENPP2抗体通过抑制肿瘤微环境中的LPA信号通路，显著减少三阴性乳腺癌的血管生成，并增强化疗药物敏感性。
4. **文献名称**：*Structural characterization of ENPP2 epitopes for therapeutic antibody development*
**作者**：Garcia R, et al.
**摘要**：通过解析ENPP2蛋白的抗原表位，研发出高特异性抗体，验证了其结合活性及对酶功能的抑制作用，为药物设计提供结构基础。
建议通过PubMed或Google Scholar搜索真实文献，关键词：**ENPP2 antibody**, **Autotaxin inhibitor**, **therapeutic targeting**。
The ENPP2 antibody targets the enzyme ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), also known as autotaxin. ENPP2 is a secreted glycoprotein that plays a critical role in lysophosphatidic acid (LPA) production by hydrolyzing lysophosphatidylcholine (LPC) to generate LPA, a bioactive lipid mediator involved in diverse physiological and pathological processes. ENPP2 is implicated in cell proliferation, migration, and survival, and its dysregulation has been linked to cancer progression, fibrosis, inflammation, and neurological disorders.
ENPP2 antibodies are essential tools for studying the enzyme’s expression, localization, and function in vitro and in vivo. They are widely used in applications such as Western blotting, immunohistochemistry (IHC), and ELISA to quantify ENPP2 levels in tissues or biological fluids, aiding research into disease mechanisms. Some antibodies specifically recognize distinct structural domains of ENPP2. such as its catalytic site or hydrophobic channel, enabling functional studies or inhibition assays.
Therapeutic interest in ENPP2 has grown due to its role in promoting tumor metastasis and angiogenesis. Neutralizing antibodies against ENPP2 are being explored as potential therapeutics to block LPA signaling in cancers or fibrotic diseases. Commercially available ENPP2 antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and validation standards, necessitating careful selection based on experimental needs.
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