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Rabbit Polyclonal KLHL36 Antibody

  • 中文名: KLHL36抗体
  • 别    名: C16orf44
货号: IPDX12983
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesC16orf44
WB Predicted band size70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human KLHL36
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是基于文献检索模拟生成的3篇关于KLHL36抗体的假设性参考文献(实际文献需通过专业数据库验证):

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1. **标题**: *KLHL36 regulates cell cycle progression via ubiquitin-mediated degradation of p21*

**作者**: Li X, et al.

**摘要**: 本研究利用KLHL36特异性抗体证实了KLHL36通过泛素-蛋白酶体系统调控p21蛋白降解,影响结肠癌细胞周期进程。抗体应用于Western blot和免疫共沉淀实验。

2. **标题**: *Expression profiling of KLHL36 in human tissues using a novel monoclonal antibody*

**作者**: Tanaka R, et al.

**摘要**: 开发了一种高特异性抗KLHL36单克隆抗体,通过免疫组化揭示KLHL36在睾丸、肝脏和甲状腺中高表达,提示其在组织特异性生理过程中的潜在作用。

3. **标题**: *KLHL36 interacts with viral capsid proteins: a proteomics study*

**作者**: Chen H, et al.

**摘要**: 通过KLHL36抗体进行免疫沉淀-质谱分析,发现其与多种病毒衣壳蛋白存在相互作用,提示KLHL36可能在宿主抗病毒应答中发挥功能。

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**备注**:

- 以上为模拟文献,实际研究中KLHL36相关抗体文献较少,建议通过PubMed或Web of Science以"KLHL36 antibody" + "ubiquitination"/"cancer"/"viral infection"等关键词组合检索最新研究。

- 部分研究可能仅在方法学中提及抗体应用,未将KLHL36作为核心研究对象。

背景信息

The KLHL36 antibody is a research tool designed to target the Kelch-like protein 36 (KLHL36), a member of the Kelch-like (KLHL) family characterized by conserved BTB/POZ, BACK, and Kelch-repeat domains. KLHL36 is implicated in ubiquitin-proteasome pathways, potentially acting as a substrate adaptor for Cullin-RING E3 ubiquitin ligase complexes, though its precise biological roles remain under investigation. Studies suggest it may regulate cellular processes such as oxidative stress responses, cell cycle progression, or protein degradation by mediating substrate-specific ubiquitination. Expression of KLHL36 has been detected in various tissues, including the brain, liver, and reproductive organs, but its tissue-specific functions are not well defined. Research using KLHL36 antibodies focuses on elucidating its expression patterns, interactions with binding partners, and involvement in diseases like cancer or neurodegenerative disorders. Commercially available KLHL36 antibodies are typically validated for applications like Western blotting, immunohistochemistry, or immunofluorescence. However, challenges persist in specificity verification due to potential cross-reactivity with homologous KLHL family members. Ongoing studies aim to clarify its physiological substrates and pathological relevance, positioning KLHL36 as a potential biomarker or therapeutic target in disease contexts.

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