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Rabbit Polyclonal CBFA2T3 Antibody

  • 中文名: CBFA2T3抗体
  • 别    名: ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3
货号: IPDX13025
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesETO2; MTG16; MTGR2; ZMYND4; RUNX1T3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CBFA2T3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CBFA2T3抗体的3篇参考文献,包含文献名称、作者及摘要概括:

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1. **文献名称**:*CBFA2T3 in hematopoiesis and leukemia: a role in transforming growth factor β signaling*

**作者**:Davis JN, et al.

**摘要**:本研究探讨了CBFA2T3(MTG16)在造血系统中的作用,利用特异性抗体验证其在TGF-β信号通路中的调控功能。通过Western blot和免疫沉淀实验,发现CBFA2T3与SMAD蛋白相互作用,可能影响白血病细胞的增殖和分化。

2. **文献名称**:*Antibody-based detection of CBFA2T3 in acute myeloid leukemia subtypes*

**作者**:Smith LM, et al.

**摘要**:该研究开发了一种高特异性CBFA2T3抗体,用于AML患者的病理分析。通过免疫组织化学和流式细胞术,发现CBFA2T3表达与特定染色体易位(如t(8;21))相关,可能作为AML分型的潜在标志物。

3. **文献名称**:*MTG16/CBFA2T3 as a tumor suppressor in colorectal cancer: antibody validation and functional studies*

**作者**:Wang Y, et al.

**摘要**:文章通过CRISPR敲除模型验证了CBFA2T3抗体的特异性,证明CBFA2T3在结直肠癌中通过抑制Wnt/β-catenin通路发挥抑癌作用。抗体应用于组织芯片分析,显示其低表达与患者预后不良相关。

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注:上述文献为示例,实际文献需通过PubMed或Web of Science检索。若需具体文章,建议使用关键词“CBFA2T3 antibody”或“MTG16 antibody”查询近年发表的实验研究。

背景信息

The CBFA2T3 antibody is designed to target the CBFA2T3 protein, encoded by the CBFA2T3 gene (also known as MTG16 or ETO2), which belongs to the ETO family of nuclear corepressors. This protein plays a critical role in transcriptional regulation, particularly in hematopoiesis and cellular differentiation, by forming complexes with chromatin-modifying enzymes and transcription factors to repress gene expression. CBFA2T3 is notably involved in chromosomal translocations associated with acute myeloid leukemia (AML), such as the t(8;21)(q22;q22) translocation that fuses CBFA2T3 with RUNX1. resulting in the RUNX1-CBFA2T3 oncoprotein. This fusion disrupts normal transcriptional programs, promoting leukemogenesis. Antibodies against CBFA2T3 are widely used in research to study its expression, localization, and interaction partners in both normal and malignant cells. They are essential tools in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in the characterization of its role in cancer biology and developmental processes. Additionally, these antibodies have potential diagnostic and therapeutic relevance, particularly in identifying AML subtypes and exploring targeted therapies for CBFA2T3-related malignancies.

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