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Rabbit Polyclonal OAS3 Antibody

  • 中文名: OAS3抗体
  • 别    名: p100; p100OAS
货号: IPDX13116
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Aliasesp100; p100OAS
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human OAS3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于OAS3抗体的3篇参考文献示例(注:文献为虚构示例,仅供格式参考):

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1. **文献名称**: *OAS3 Expression in Viral Infections: A Biomarker for Interferon Response*

**作者**: Smith A, et al.

**摘要**: 本研究通过Western blot和免疫荧光技术,利用特异性OAS3抗体,揭示了在丙型肝炎病毒(HCV)感染模型中,OAS3蛋白的表达水平显著上调,且与干扰素-α的激活呈正相关,提示其可作为抗病毒免疫反应的潜在标志物。

2. **文献名称**: *OAS3 Autoantibodies in Systemic Lupus Erythematosus*

**作者**: Chen L, et al.

**摘要**: 通过ELISA和蛋白质印迹法检测系统性红斑狼疮(SLE)患者血清,发现OAS3自身抗体阳性率显著高于健康对照组,提示OAS3抗体可能参与SLE的自身免疫病理机制,或成为疾病分层的生物标志物。

3. **文献名称**: *OAS3 Antibody Validation for Immunohistochemical Staining in Glioblastoma*

**作者**: Wang X, et al.

**摘要**: 研究验证了一种高特异性OAS3单克隆抗体在脑胶质瘤组织中的染色效能,发现OAS3蛋白的高表达与患者生存期缩短相关,表明其在肿瘤微环境中的潜在促癌作用。

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**备注**:以上文献为示例,实际研究中建议通过PubMed或Web of Science检索真实发表的论文。

背景信息

The OAS3 (2'-5'-oligoadenylate synthetase 3) antibody is a tool used to study the OAS3 protein, a key component of the innate immune response against viral infections. OAS3 belongs to the oligoadenylate synthetase family, which is interferon-inducible and activated by double-stranded RNA (dsRNA) produced during viral replication. Upon activation, OAS3 catalyzes the synthesis of 2'-5'-oligoadenylates (2-5A), which bind to and activate RNase L, triggering RNA degradation to inhibit viral proliferation. OAS3 is the largest isoform in the OAS family, with distinct structural features and higher enzymatic activity compared to OAS1 and OAS2. It is expressed in various tissues, including immune cells, and plays roles beyond antiviral defense, such as modulating inflammation and cell death pathways. Research using OAS3 antibodies has linked its dysregulation to autoimmune diseases (e.g., systemic lupus erythematosus), neurodegenerative disorders, and cancer progression. These antibodies are essential for detecting OAS3 expression levels, localization, and interactions in experimental models, aiding in understanding its role in viral pathogenesis (e.g., hepatitis C, SARS-CoV-2) and immune regulation. Commercial OAS3 antibodies are typically validated for applications like Western blotting, immunofluorescence, and ELISA, with specificity confirmed via knockout controls.

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