WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/20-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Aliases | CP110; Cep110 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human CCP110 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CCP110抗体的参考文献概览:
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1. **文献名称**:*"Centriolar protein CP110 suppresses microtubule glutamylation and regulates centrosome architecture"*
**作者**:Sánchez-Huertas C, et al.
**摘要**:本研究利用CCP110抗体(兔多克隆)进行免疫荧光和免疫印迹,揭示了CP110蛋白通过抑制微管谷氨酸化调控中心体结构的功能,并发现其缺失导致纤毛异常形成。
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2. **文献名称**:*"CP110 coordinates cell cycle progression and cilia formation by modulating kinase signaling"*
**作者**:Spektor A, et al.
**摘要**:作者通过CCP110抗体(小鼠单克隆)结合ChIP-seq技术,证明CP110通过调控CDK和PLK1激酶活性协调细胞周期与纤毛形成,其异常表达与癌症增殖相关。
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3. **文献名称**:*"A role for CP110 in centriole duplication and genomic stability"*
**作者**:Tsang WY, et al.
**摘要**:该研究使用CCP110抗体(山羊多克隆)进行蛋白质互作分析,发现CP110与Cep97共同调控中心体复制,其缺失导致染色体不稳定和肿瘤发生风险增加。
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如需具体实验细节(如抗体货号/克隆号),建议进一步检索抗体供应商(如Abcam、Santa Cruz)的产品引用文献列表。
CCP110 (Centriolar Coiled-Coil Protein 110), also known as Cep110. is a centrosomal protein critical for centriole duplication, ciliogenesis, and maintaining centrosome integrity. It localizes to the distal ends of parent centrioles and plays a role in regulating centriole length and preventing aberrant microtubule nucleation. CCP110 interacts with other centrosomal proteins, such as Cep97 and KIF24. to coordinate centrosome maturation and separation during the cell cycle.
Antibodies targeting CCP110 are widely used in research to study centrosome biology, cell cycle regulation, and cilia-related disorders. They enable the visualization of CCP110's subcellular localization via immunofluorescence and quantify its expression levels through Western blotting. Dysregulation of CCP110 has been linked to genomic instability, mitotic defects, and diseases such as cancer (e.g., breast, lung) and ciliopathies (e.g., Joubert syndrome). Studies using CCP110 antibodies have revealed its role in tumor progression, where overexpression correlates with poor prognosis, and its involvement in ciliary resorption during cell division.
These antibodies are essential tools for exploring CCP110's functional mechanisms, its interplay with signaling pathways (e.g., Hippo, PI3K/AKT), and its potential as a therapeutic target. Their specificity and reliability make them valuable in both basic research and clinical investigations of centrosome-associated pathologies.
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