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Rabbit Polyclonal BICRA Antibody

  • 中文名： BICRA抗体
  • 别    名： GLTSCR1
货号: IPDX13466
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesGLTSCR1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human BICRA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于BICRA抗体的虚构参考文献示例(请注意，这些文献为示例，实际文献需通过学术数据库检索确认)：

1. **文献名称**：*"BICRA Antibody Validation in Chromatin Remodeling Studies"*

**作者**：Zhang et al.

**摘要**：开发并验证了一种高特异性BICRA抗体，用于检测染色质重塑复合体SWI/SNF中BICRA的相互作用，通过免疫沉淀和质谱分析证实其功能关联。

2. **文献名称**：*"Role of BICRA in Pediatric Glioma Pathogenesis"*

**作者**：Thompson et al.

**摘要**：利用BICRA抗体进行免疫组化分析，发现BICRA蛋白在儿童胶质瘤中表达显著降低，提示其作为肿瘤抑制因子的潜在作用。

3. **文献名称**：*"BICRA Mutations and Protein Stability in Neurodevelopmental Disorders"*

**作者**：Garcia-Rodriguez et al.

**摘要**：通过Western blot和免疫荧光技术(使用BICRA抗体)，研究BICRA基因突变导致的蛋白稳定性变化及其与神经发育异常的关联。

4. **文献名称**：*"Commercial BICRA Antibody Cross-Reactivity Analysis"*

**作者**：Wang et al.

**摘要**：评估市售BICRA抗体的特异性，发现部分抗体存在与非靶标蛋白的交叉反应，提出优化实验条件的建议。

**建议**：实际文献可通过PubMed或Google Scholar检索关键词“BICRA antibody”、“GLTSCR1 antibody”或“BAF complex antibody”获取，并关注近年发表的抗体开发或功能研究论文。

背景信息

The BICRA (BRD4-interacting chromatin remodeling complex-associated) protein, encoded by the BICRA gene, is a component of chromatin remodeling complexes that regulate gene expression by modifying chromatin structure. Initially identified as a binding partner of BRD4—a bromodomain protein involved in transcriptional elongation and epigenetic regulation—BICRA plays a role in mediating interactions between chromatin remodelers and transcriptional machinery. It is implicated in neural development, differentiation, and cellular homeostasis. Mutations in BICRA have been linked to Coffin-Siris syndrome (CSS), a rare genetic disorder characterized by developmental delays, intellectual disability, and distinct facial features. Additionally, BICRA alterations are observed in certain cancers, suggesting potential roles in oncogenesis. Antibodies targeting BICRA are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They enable researchers to investigate BICRA's involvement in chromatin remodeling pathways, its interplay with BRD4. and its contribution to developmental disorders and cancer biology. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of BICRA's molecular mechanisms and therapeutic potential.

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