关键信息
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基因名
Endoglycan/PODXL2
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简介
The endocan/PODXL2 protein serves as a ligand for angioselectin, enabling leukocytes to rapidly roll on the vascular surface through high-affinity divalent cation-dependent interactions with E-, P-, and L-selectin. Through disulfide bonds, the protein forms homodimers and interacts with specific selectins, including SELL, SELE, and SELP. Endoglycan/PODXL2 Protein, Human (HEK293, His) is the recombinant human-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
Endoglycan; PODLX2; brain-1; BRN1; EG; oct-8; OTF8; UNQ1861/PRO3742
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZ53-1
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表达区间
G33-T500
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蛋白长度
Extracellular Domain
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分子量
70-115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Endoglycan, also known as PODXL2, is a member of the Podocalyxin-like family of glycoproteins, which are primarily expressed in endothelial cells and play a crucial role in cellular processes such as migration, adhesion, and signaling. Researchers have identified Endoglycan as a key player in various physiological and pathological conditions, including cancer progression, inflammation, and organ development. Its unique structure, characterized by a heavily glycosylated extracellular domain, facilitates interactions with the extracellular matrix and other cell types, making it essential for maintaining vascular integrity and cell behavior. Given its involvement in significant biological processes and its potential as a biomarker for certain diseases, the production of recombinant Endoglycan protein has garnered interest for both basic research and therapeutic applications. The ability to produce this protein in suitable expression systems facilitates studies into its functional properties, molecular interactions, and potential use in targeted therapies. As researchers delve into the multifaceted roles of Endoglycan in health and disease, understanding its biochemical characteristics and pathways may provide insights into novel therapeutic approaches for conditions where this glycoprotein is implicated. This ongoing research not only sheds light on fundamental cellular mechanisms but also paves the way for innovative strategies in regenerative medicine and cancer therapy, wherein modulation of Endoglycan's activity could lead to improved patient outcomes.
