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Rabbit Monoclonal PEX19 Antibody

  • 中文名: PEX19抗体
  • 别    名: HK33; PBD12A; Peroxin 19; PEX19; PMP1; PMPI; PXF; PXMP1;;PEX19
货号: IPDX18832
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHK33; PBD12A; Peroxin 19; PEX19; PMP1; PMPI; PXF; PXMP1;;PEX19
WB Predicted band sizeCalculated MW: 33 kDa ; Observed MW: 35,40 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthesized peptide derived from human PEX19
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于PEX19抗体的代表性文献(信息已简化概括):

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1. **文献名称**:*PEX19 is a chaperone and stabilizer of monomeric PEX5*

**作者**:Francisco et al.

**摘要**:研究利用PEX19抗体验证其在过氧化物酶体膜蛋白PEX5转运中的作用,发现PEX19通过结合PEX5单体维持其稳定性,防止错误聚集。

2. **文献名称**:*Zellweger syndrome mutations in PEX19 disrupt peroxisome membrane synthesis*

**作者**:Matsuzono et al.

**摘要**:通过PEX19抗体检测患者细胞,揭示齐德尔综合征相关PEX19突变导致过氧化物酶体膜蛋白无法定位,阐明了该疾病的分子机制。

3. **文献名称**:*PEX19 binds multiple peroxisomal membrane proteins via distinct sites*

**作者**:Sato et al.

**摘要**:利用免疫共沉淀(Co-IP)和PEX19抗体,证明PEX19通过不同结构域结合多种过氧化物酶体膜蛋白,协调其定向运输至细胞器膜。

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**提示**:如需具体实验中的抗体使用细节(如品牌、货号),建议在PubMed等平台以“PEX19 antibody [应用技术]”(如Western blot、IF)为关键词筛选近期文献。

背景信息

The PEX19 antibody is a crucial tool in studying peroxisome biogenesis and related disorders. PEX19. a 299-amino acid protein, functions as a cytosolic chaperone and import receptor essential for peroxisomal membrane protein (PMP) targeting and membrane assembly. It binds nascent PMPs via conserved motifs, facilitating their delivery to peroxisomes through interaction with PEX3 on the organelle membrane. Dysfunctional PEX19 disrupts peroxisome formation, leading to severe metabolic disorders such as Zellweger spectrum disorders (ZSDs), characterized by neurological impairments and multisystem dysfunction. Antibodies targeting PEX19 enable researchers to detect its expression, localization, and interactions in cellular models. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to investigate peroxisome biogenesis mechanisms, disease pathogenesis, and potential therapeutic strategies. Commercially available PEX19 antibodies are typically raised in rabbits or mice, with validation in human, mouse, and rat samples. Recent studies also explore PEX19's role beyond peroxisomes, including lipid metabolism and viral infection pathways, expanding the antibody's research applications. Proper validation using knockout controls remains critical due to potential cross-reactivity with structurally similar chaperones.

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