关键信息
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基因名
ADCY5
- 应用
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别名
Adenylate cyclase type V; ATP pyrophosphate-lyase 5
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95622
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表达区间
Gly167~Glu385
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分子量
28kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ADCY5 (Adenylate Cyclase 5) is a crucial enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP), a key secondary messenger that regulates various physiological processes including neurotransmission, hormone secretion, and cardiac function. Mutations in the ADCY5 gene have been linked to various neurological disorders, particularly familial dyskinesia with facial myokymia, highlighting its significance in cellular signaling pathways. Research into ADCY5 recombinant proteins aims to elucidate the enzyme’s structure-function relationship, understand its role in pathophysiology, and explore potential therapeutic targets. The production of ADCY5 recombinant protein enables detailed biochemical studies, including activity assays and interaction studies with regulatory proteins or ligands. This research not only provides insights into the molecular mechanisms of disease associated with ADCY5 mutations but also facilitates the development of targeted therapies to modulate cAMP levels in affected tissues. Furthermore, understanding ADCY5's regulatory mechanisms can illuminate broader physiological effects and contribute to the advancement of knowledge in both basic and applied biomedical research.
