关键信息
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基因名
GRIK2
- 应用
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别名
EAA4; GLR6; GLUR6; GluK2; Excitatory amino acid receptor 4; Glutamate receptor 6
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13002
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表达区间
Asn286~Pro561
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分子量
32kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GRIK2, a gene encoding the Glutamate Ionotropic Receptor Kainate Type Subunit 2, plays a crucial role in synaptic transmission and neurological processes, particularly in learning and memory. Dysregulation of GRIK2 has been associated with various neuropsychiatric disorders, including schizophrenia, depression, and epilepsy. To better understand its function and therapeutic potential, researchers have focused on producing recombinant GRIK2 proteins. These recombinant proteins allow for detailed biochemical and pharmacological studies, enabling scientists to investigate the structure-function relationships of the receptor, its interaction with ligands, and its signaling pathways. Advances in protein expression techniques, such as using mammalian cell systems, have improved the yield and functionality of recombinant GRIK2, making it a valuable tool for studying receptor dynamics in vitro. Furthermore, the development of high-throughput screening assays utilizing these recombinant proteins holds promise for discovering novel compounds that can modulate GRIK2 activity. Understanding the precise role of GRIK2 in neuronal function could pave the way for targeted therapies to treat related neurological conditions, thereby highlighting the significance of GRIK2 recombinant protein research in neuroscience.
