| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TSNAX |
| Uniprot No | Q99598 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-290aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSMSNKEGS GGFRKRKHDN FPHNQRREGK DVNSSSPVML AFKSFQQELD ARHDKYERLV KLSRDITVES KRTIFLLHRI TSAPDMEDIL TESEIKLDGV RQKIFQVAQE LSGEDMHQFH RAITTGLQEY VEAVSFQHFI KTRSLISMDE INKQLIFTTE DNGKENKTPS SDAQDKQFGT WRLRVTPVDY LLGVADLTGE LMRMCINSVG NGDIDTPFEV SQFLRQVYDG FSFIGNTGPY EVSKKLYTLK QSLAKVENAC YALKVRGSEI PKHMLADVFS VKTEMIDQEE GIS |
| 预测分子量 | 35 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设性的参考文献示例(TSNAX重组蛋白的相关研究可能为虚构或需核实名称准确性)：
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1. **"高效表达与纯化TSNAX重组蛋白及其功能研究"**
作者：Zhang L, et al.
摘要：本研究利用大肠杆菌表达系统成功制备TSNAX重组蛋白，通过亲和层析纯化获得高纯度产物，并验证其在细胞粘附中的调控作用。
2. **"TSNAX重组蛋白在神经退行性疾病模型中的保护效应"**
作者：Kim S, et al.
摘要：通过动物实验发现，外源性TSNAX重组蛋白可减少β淀粉样蛋白沉积，改善阿尔茨海默病模型小鼠的认知功能，提示其潜在治疗价值。
3. **"TSNAX重组蛋白的结构解析与受体结合机制"**
作者：Wang Y, et al.
摘要：采用X射线晶体学解析TSNAX重组蛋白的三维结构，揭示其与Integrin α5β1受体的特异性结合位点，为靶向药物设计提供依据。
4. **"基于CHO细胞的大规模TSNAX重组蛋白生产工艺优化"**
作者：Müller J, et al.
摘要：开发了CHO细胞稳定表达TSNAX重组蛋白的工业化生产流程，通过培养基优化使产量提升3倍，满足临床级应用需求。
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**注意**：以上内容为示例，实际文献需通过PubMed、Web of Science等数据库检索确认。若"TSNAX"为笔误或非常规术语，建议核对正确名称(如TSG6、TRAX等)。
**Background of TSNAX Recombinant Protein**
TSNAX (Translin-associated protein X), also known as TRAX, is a highly conserved protein that forms a stable heteromeric complex with Translin (TSN). This complex plays a multifaceted role in nucleic acid metabolism, including RNA interference, DNA repair, and transcriptional regulation. Structurally, TSNAX lacks enzymatic activity but facilitates interactions with RNA and DNA through its binding partner TSN, enabling the complex to participate in critical cellular processes such as gene silencing, microRNA processing, and genomic stability maintenance.
The TSNAX-TSN complex has been implicated in neurodevelopment and synaptic plasticity, with studies linking its dysfunction to neuropsychiatric disorders like schizophrenia and autism spectrum disorders. Additionally, TSNAX is involved in cancer biology, where its aberrant expression correlates with tumor progression, metastasis, and chemoresistance. For instance, TSNAX overexpression in certain cancers modulates apoptotic pathways and enhances cell survival under stress.
Recombinant TSNAX protein is produced using biotechnological platforms (e.g., bacterial or mammalian expression systems) to ensure high purity and bioactivity. Its production enables functional studies, such as elucidating molecular mechanisms in RNA/DNA binding, protein-protein interactions, and therapeutic target validation. In research, recombinant TSNAX serves as a tool for investigating its role in neurodegenerative diseases, cancer pathways, and developmental biology. It also aids in drug screening assays aimed at modulating TSNAX-TSN activity for therapeutic interventions.
Overall, TSNAX recombinant protein is a vital reagent for advancing our understanding of cellular nucleic acid dynamics and its implications in health and disease.
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