Recombinant Human CCL11 protein

CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1. is a small cytokine belonging to the CC chemokine family. It plays a critical role in recruiting eosinophils and other immune cells to sites of inflammation by interacting with its primary receptor CCR3. Initially identified for its involvement in allergic responses, CCL11 is implicated in conditions like asthma, atopic dermatitis, and eosinophilic disorders. Beyond immunology, emerging research links CCL11 to neuroinflammation and age-related cognitive decline, with elevated levels observed in Alzheimer’s disease and aging brains, earning it the informal label "the aging chemokine."

Recombinant CCL11 protein is produced using engineered bacterial (e.g., E. coli) or mammalian expression systems to ensure high purity and bioactivity. The non-glycosylated form, typically around 8-10 kDa, retains functional properties despite lacking post-translational modifications. Its applications span in vitro studies to investigate chemotaxis, immune cell signaling, and inflammatory pathways, as well as in vivo models of allergic diseases or neurological disorders. Researchers also utilize it to explore therapeutic interventions targeting CCR3-mediated pathways. Quality-controlled batches are essential for reproducibility, often validated through cell migration assays and receptor-binding tests. As a potential biomarker, recombinant CCL11 aids in standardizing diagnostic assays for clinical research. Its dual role in immunity and neurodegeneration continues to drive interdisciplinary interest in both therapeutic and mechanistic studies.