关键信息
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基因名
K3L
- 应用
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别名
K3L; Protein K3
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种属
Vaccinia virus
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20639
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表达区间
1-88aa
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分子量
26.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The K3L protein, derived from the vaccinia virus, has garnered significant attention in molecular biology and virology due to its unique ability to inhibit host cell antiviral responses. Research into K3L has primarily focused on its role as a sense RNA-binding protein that prevents the phosphorylation of eIF2α (eukaryotic translation initiation factor 2 alpha), thereby allowing viral mRNA to be translated in the presence of interferon-induced stress. This characteristic makes K3L a potential candidate for studying viral mechanisms of immune evasion and has implications for developing novel antiviral therapies. The investigation of K3L also provides insights into the intricate interactions between viruses and host cells, contributing to our understanding of pathogenesis and immune response modulation. Furthermore, the study of K3L's structural and functional properties aids in the exploration of targeted strategies in vaccine design and therapeutic interventions against viral infections. Researchers are continually unraveling the nuances of K3L's interactions at the molecular level, revealing its potential as a model for understanding viral resistance and the broader implications for infectious disease control.
